183960-69-2

Upstream product

• 183960-57-8 (4R)-4-benzyl-3-{(2R)-2-[(2S,4S,5S,6S)-6-((1S)-3-bromo-1-methyl-3-butenyl)-5-methyl-2-phenyl-m-dioxan-4-yl]propionyl}-2-oxazolidinone 
• 183960-80-7 (4R)-4-benzyl-3-((2R,3S,4R,5S,6S)-8-bromo-3,5-dihydroxy-2,4,6-trimethyl-1-oxo-8-nonenyl)-2-oxazolidinone 
• 183960-55-6 (4R)-4-benzyl-3-((2R,4R,5S,6S)-8-bromo-5-hydroxy-2,4,6-trimethyl-1,3-dioxo-8-nonenyl)-2-oxazolidinone 
• 183960-51-2 (4R)-4-benzyl-3-((2S)-4-bromo-2-methyl-1-oxo-4-pentenyl)-2-oxazolidinone 
• 113453-47-7 (S)-4-bromo-2-methylpent-4-enal 
• 104410-48-2 (2S)-4-bromo-2-methyl-4-penten-2-ol 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 183960-68-1 (R)-4-Benzyl-3-{(R)-2-[(2S,4S,5R,6S)-5-methyl-2-phenyl-6-((1S,5R,6S,7S,8R)-1,5,7-trimethyl-3-methylene-4-oxo-6-triethylsilanyloxy-8-triisopropylsilanyloxy-nonyl)-[1,3]dioxan-4-yl]-propionyl}-oxazolidin-2-one 
• 183960-82-9 (R)-4-Benzyl-3-((2R,3S,4S,5R)-2,4-dimethyl-3-triethylsilanyloxy-5-triisopropylsilanyloxy-hexanoyl)-oxazolidin-2-one 
• 183960-62-5 (R)-4-Benzyl-3-((2R,3S,4R,5R)-3-hydroxy-2,4-dimethyl-5-triisopropylsilanyloxy-hexanoyl)-oxazolidin-2-one 
• 211187-45-0 (4R)-4-benzyl-3-((2R,3S,4S,5R)-3,5-dihydroxy-2,4-dimethyl-1-oxohexyl)-2-oxazolidinone 
• 184178-78-7 (4R)-4-benzyl-3-((2R,4S,5R)-5-hydroxy-2,4-dimethyl-1,3-dioxohexyl)-2-oxazolidinone 
• 183960-66-9 (2R,3S,4S,5R)-2,4-Dimethyl-3-triethylsilanyloxy-5-triisopropylsilanyloxy-hexanoyl chloride 
• 183960-64-7 (2R,3S,4S,5R)-2,4-Dimethyl-3-triethylsilanyloxy-5-triisopropylsilanyloxy-hexanoic acid 

Downstream Products

• 211187-44-9 (R)-2-[(2S,4S,5R,6S)-6-((S)-2-{(R)-2-[(1S,2R,3S,4R,5R)-1-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-2,4-dimethyl-5-triisopropylsilanyloxy-hexyl]-oxiranyl}-1-methyl-ethyl)-5-methyl-2-phenyl-[1,3]dioxan-4-yl]-propionic acid 
• 211187-42-7 (R)-4-Benzyl-3-{(R)-2-[(2S,4S,5R,6S)-6-((S)-2-{(R)-2-[(1S,2R,3S,4R,5R)-1-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2,4-dimethyl-5-triisopropylsilanyloxy-hexyl]-oxiranyl}-1-methyl-ethyl)-5-methyl-2-phenyl-[1,3]dioxan-4-yl]-propionyl}-oxazolidin-2-one 
• 211187-40-5 (R)-4-Benzyl-3-[(R)-2-((2S,4S,5R,6S)-6-{(S)-2-[(R)-2-((1S,2R,3R,4R,5R)-1,3-dihydroxy-2,4-dimethyl-5-triisopropylsilanyloxy-hexyl)-oxiranyl]-1-methyl-ethyl}-5-methyl-2-phenyl-[1,3]dioxan-4-yl)-propionyl]-oxazolidin-2-one 

Relevant academic research and scientific papers

General strategies toward the syntheses of macrolide antibiotics. The total syntheses of 6-deoxyerythronolide B and oleandolide

The asymmetric syntheses of 6-deoxyerythronolide B (1) and oleandolide (2) have been achieved, each in 18 linear steps. These syntheses demonstrate the utility of chiral β-keto imide building block 3 as a versatile building block for the aldol-based assemblage of polypropionate-derived natural products.