183986-47-2

Upstream product

• 1197-58-6 1-(isocyanomethyl)-4-methoxybenzene 
• 215813-55-1 2-Chloro-1-(4-methoxyphenyl)ethanone-O-methyloxime 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 17061-63-1 N-(4-methoxybenzyl)formamide 
• 183986-42-7 3-Isocyano-1,3-bis-(4-methoxy-phenyl)-propan-1-one O-methyl-oxime 

Relevant academic research and scientific papers

1,3-Diphenylpropan-1,3-diamines IX. Reaction of α-Chlorooxime Ethers with α-Lithiobenzylamines

The carbanions of the benzylamine derivatives 1-4 have been reacted with α-chlorooxime ether 5 in order to get precursors of 1,3-diphenylpropane-1,3-diamines.Isonitrile 1 afforded the expected result, whereas lithiated benzamide 2 underwent oxidative dimerization and transmetallated chlorooxime derivative 5.Isoxazolidine 3 gave the condensation product 21 as a mixture of diastereomers; treatment of imine 4 led to the desired amine-oxime 15 in low yield. - Keywords: 1,3-Diphenylpropane-1,3-diamines; Benzylamine carbanions; α-Chloroacetophenone-oxime O-methyl ether