1197-58-6

Basic information

• Product Name: 4-METHOXYBENZYL ISOCYANIDE
• Synonyms: 4-METHOXYBENZYL ISOCYANIDE;HANSA ISN-0033;BIO-FARMA BF001956;1-Isocyanomethyl-4-methoxy-benzene
• CAS NO: 1197-58-6
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.17
• Mol File: 1197-58-6.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 90-95 °C(Press: 0.005 Torr)
• Appearance: /
• CAS DataBase Reference: 4-METHOXYBENZYL ISOCYANIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXYBENZYL ISOCYANIDE(1197-58-6)
• EPA Substance Registry System: 4-METHOXYBENZYL ISOCYANIDE(1197-58-6)

Safety Data

• Hazardous Substances Data: 1197-58-6(Hazardous Substances Data)

Usage

General Description

4-Methoxybenzyl isocyanide is a chemical compound with the molecular formula C9H9NO. It is also known as p-methoxybenzyl isocyanide or p-anisyl isocyanide. 4-METHOXYBENZYL ISOCYANIDE is a clear, colorless to slightly yellow liquid with a pungent, disagreeable odor. It is used as a building block in organic synthesis, particularly in the preparation of complex organic molecules. 4-Methoxybenzyl isocyanide is known for its ability to react with various functional groups, making it a versatile reagent in chemical reactions. 4-METHOXYBENZYL ISOCYANIDE is also known for its toxicity and should be handled with caution.

InChI:InChI=1/C9H9NO/c1-10-7-8-3-5-9(11-2)6-4-8/h3-6H,7H2,2H3

Upstream product

• 2746-25-0 p-Methoxybenzyl bromide 
• 1895-39-2 sodium chlorodifluoroacetate 
• 2393-23-9 4-methoxy-benzylamine 
• 123-11-5 4-methoxy-benzaldehyde 
• 6343-93-7 2-(4-methoxyphenyl)acetamide 
• 67-66-3 chloroform 
• 17061-63-1 N-(4-methoxybenzyl)formamide 

Downstream Products

• 180588-22-1 1-(4-Methoxy-benzyl)-4-[(Z)-4-methoxy-benzylimino]-1,3-diaza-spiro[4.4]nonane-2-thione 
• 229974-87-2 (2S,4S)-N-<4-isocyano-4-(4-methoxyphenyl)-1-phenyl-2-butyl>-p-toluenesulfonamide 
• 229974-88-3 (2S,4R)-N-<4-isocyano-4-(4-methoxyphenyl)-1-phenyl-2-butyl>-p-toluenesulfonamide 
• 588708-21-8 N-acetyl-N-(4-methoxybenzyl)-α,α-diethylglycine 4-methoxybenzyl amide 
• 588708-25-2 N-acetyl-N-(4-methoxybenzyl)-α,α-dipropylglycine 4-methoxybenzyl amide 
• 588708-30-9 N-acetyl-N-(4-methoxybenzyl)-α,α-dibenzylglycine 4-methoxybenzyl amide 
• 17183-62-9 2-diethylamino-N-(4-methoxybenzyl)-2-phenylacetamide 

Relevant articles and documents

(o-Phenylenediamino)borylstannanes: Efficient Reagents for Borylation of Various Alkyl Radical Precursors

(o-Phenylenediamino)borylstannanes were newly synthesized to achieve radical boryl substitutions of a variety of alkyl radical precursors. Dehalogenative, deaminative, decharcogenative, and decarboxylative borylations proceeded in the presence of a radica

Synthesis of isocyanides by reacting primary amines with difluorocarbene

A general, convenient, and friendly route for preparing a versatile building block of isocyanides from primary amines is developed. Difluorocarbene, generated in situ from decarboxylation of chlorodifluoroacetate, reacts efficiently with primary amines to produce isocyanides. Various primary amines are well tolerated, including aryl, heteroaryl, benzyl, and alkyl amines, as well as amine residues in amino acids and peptides. Late-stage functionalization of biologically active amines is demonstrated, showing its practical capacity in drug design and peptide modification.

Nonacidic Farnesoid X Receptor Modulators

As a cellular bile acid sensor, farnesoid X receptor (FXR) participates in regulation of bile acid, lipid and glucose homeostasis, and liver protection. Clinical results have validated FXR as therapeutic target in hepatic and metabolic diseases. To date, potent FXR agonists share a negatively ionizable function that might compromise their pharmacokinetic distribution and behavior. Here we report the development and characterization of a high-affinity FXR modulator not comprising an acidic residue.