183990-46-7Relevant academic research and scientific papers
Use of oligosalicylates in the preparation of phenolic amido acids
Gschneidner, David,Corvino, JoAnne,Freeman, John,O'Toole, Doris,Shields, Lynn,Wang, Eric
, p. 1567 - 1575 (2005)
A simplified methodology has been developed for preparing salicylamides from the corresponding acids via oligosalicylates which both protect the phenolic group and, at the same time, activate the carboxyl for coupling. Copyright Taylor & Francis, Inc.
Development and in Vitro and in Vivo evaluation of microspheres containing sodium N-[8-(2-hydroxybenzoyl)amino]caprylate for the oral delivery of berberine hydrochloride
Li, Ying,Zhu, Chunyan
, (2020)
Microspheres containing absorption enhancer (sodium N-[8-(2-hydroxybenzoyl) amino]caprylate, SNAC) were developed to enhance the oral bioavailability of berberine hydrochloride (BER) with poor intestinal membrane permeability. Microspheres were prepared a
Synthesis method of sodium N-(8-[2-hydroxybenzoyl]-amino)caprylate
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Paragraph 0027; 0030-0033; 0035-0038; 0040-0043, (2022/01/08)
The present invention discloses a method for synthesizing N- (8-[2-hydroxybenzoyl]- amino) sodium caprylate. First, methyl o-hydroxybenzoate was added to the reaction vessel, and then a solvent and 8-aminocaprylic acid were added to the reaction; after th
Preparation method of N-(8-[2-hydroxybenzoyl]-amino) sodium caprylate and intermediate thereof
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Paragraph 0076; 0082-0083; 0086; 0091-0092; 0095; 0100-0101, (2021/06/06)
The invention discloses a preparation method of N-(8-[2-hydroxybenzoyl]-amino) sodium caprylate and an intermediate thereof, and the preparation method of the intermediate comprises the following steps: reacting salicylamide with a protecting group reagen
Method for preparing N-[8-(2-hydroxybenzoyl)amino]caprylic acid
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Paragraph 0042; 0058-0061; 0062; 0077-0078, (2021/07/01)
The invention provides a method for preparing N-[8-(2-hydroxybenzoyl)amino]caprylic acid. The method is characterized in that salicylamide is used as an initial raw material and subjected to four-step reactions including cyclization, two-step nucleophilic substitution, hydrolysis and decarboxylation to obtain the N-[8-(2-hydroxybenzoyl)amino]caprylic acid. The preparation method has the advantages of easily available raw materials, low production cost, less three-waste pollution, simple process route and easy industrial production, and solves the problems that existing preparation methods are complex, raw materials are not easily available, requirements on equipment are low, and impurities are easily generated.
Sodium 8-(2-hydroxylbenzamido)caprylate and preparation method therefor
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, (2020/12/08)
The invention discloses sodium 8-(2-hydroxylbenzamido)caprylate and a preparation method therefor and belongs to the field of preparation of compounds. A key of the technical scheme of the invention is as follows: the preparation method comprises the step
Preparation method of sodium 8-[(2-hydroxybenzoyl) amino] octanoate
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, (2018/11/04)
The invention discloses a preparation method of a pharmaceutical intermediate, i.e., sodium 8-[(2-hydroxybenzoyl) amino] octanoate. The preparation method comprises the steps of enabling salicylamide,used as a raw material, to react with N' N-carbonyl dii
METHOD OF TREATING VITAMIN B12 DEFICIENCY
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Page/Page column 6, (2009/06/27)
A method and composition for treating vitamin B12 deficiency in mammals that fail to respond to oral vitamin B12 therapy, including preparing a pharmaceutical composition for oral administration containing vitamin B12 and at least one substance selected f
METHODS FOR PRODUCING N-(8-[2-HYDROXYBENZOYL]-AMINO) CAPRYLIC ACID
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Page/Page column 4-5, (2008/06/13)
Disclosed are improved methods for the synthesis of N-(8-[2-hydroxybenzoyl]-amino)caprylic acid. Certain compounds have been found useful for preventing the formation of a colored impurity when included in an ester hydrolysis reaction. Conducting ester hy
Compounds and compositions for delivering active agents
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Page column 29 - 30, (2008/06/13)
The present invention provides a compound having the formula or a salt thereof which facilitates the delivery of active agents. Compositions and dosage unit forms comprising the compound of the present invention and at least one active agent, such as a peptide, mucopolysaccharide, carbohydrate, or a lipid, are also provided. Methods of administration and preparation of the compounds and compositions of the invention are provided as well.
