183999-28-2

Upstream product

• 111-25-1 1-bromo-hexane 
• 13071-59-5 3-benzyloxypropan-1,2-diol 
• 15028-56-5 4-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxolane 
• 100-39-0 benzyl bromide 

Downstream Products

• 183999-18-0 Phosphoric acid dibenzyl ester 2,3-bis-hexyloxy-propyl ester 
• 183999-10-2 Phosphoric acid benzyl ester 2,3-bis-hexyloxy-propyl ester methyl ester 

Relevant academic research and scientific papers

Synthesis, structure-activity relationships, and the effect of polyethylene glycol on inhibitors of phosphatidylinositol-specific phospholipase C from Bacillus cereus

Substrate analog inhibitors of Bacillus cereus phosphatidylinositol- specific phospholipase C (PI-PLC) were synthesized and screened for their suitability to map the active site region of the enzyme by protein crystallography. Analogs of the natural subst

Synthesis of isosteric and isopolar phosphonate substrate analogues designed as inhibitors for phosphatidylinositol-specific phospholipase C from Bacillus cereus

The synthesis of the isosteric phosphonate substrate analogue inhibitor 2 and the isopolar difluoromethylenephosphonate inhibitor 3 for phosphatidylinositol-specific phospholipase C (PI-PLC) from Bacillus cereus is described. The key step involved a trichloroacetonitrile mediated condensation between the inositol derivative 8 and the corresponding phosphonic acids 16 and 18 to establish the central P-O bond in these inhibitors.