184099-84-1

Upstream product

• 372-18-9 1,3-Difluorobenzene 
• 625-36-5 2-chloropropionyl chloride 

Downstream Products

• 1207512-21-7 (+/-)-1-benzyl-5-(2,4-difluorophenyl)-1,4-diazepane 
• 861709-19-5 C₁₈H₁₉F₂NO 

Relevant academic research and scientific papers

4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES

Compounds of the formula (I), in which the substituents are as defined in claim 1, are suitable for use as nematicides.

DIAZEPINE AND DIAZOCANE COMPOUNDS AS MC4 AGONISTS

The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, L and n are as defined in the specification. These compounds are useful as MC4 agonists.

QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS

Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of Formula (Ia) or (Ib), a pharmaceutically acce

Quinoline derivatives as antibacterial agents

The present invention relates to the use of a compound for the manufacture of a medicament for the treatment of a bacterial infection, said compound being a compound of formula a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof or a N-oxide form thereof, wherein R1 is hydrogen, halo, polyhaloC1-6alkyl, C1-6alkyl, Ar or Het; p is an integer equal to 1 or 2; R2 is C1-6alkyloxy, C1-6alkyloxyC1-6alkyloxy or C1-6alkylthio; R3 is Ar, Het or Het1; R4 and R5 each independently are hydrogen, C1-6alkyl or benzyl; or R4 and R5 together and including the N to which they are attached may form a radical selected from the group of pyrrolidinyl, 2-pyrrolinyl, 3-pyrrolinyl, pyrrolyl, imidazolidinyl, pyrazolidinyl, 2-imidazolinyl, 2-pyrazolinyl, imidazolyl, pyrazolyl, triazolyl, piperidinyl, pyridinyl, piperazinyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, morpholinyl and thiomorpholinyl, each of said rings may optionally be substituted with C1-6alkyl, halo, polyhaloC1-6alkyl, hydroxy, hydroxyC1-6alkyl, C1-6alkyloxy, amino, mono- or di(C1-6alkyl)amino, C1-6alkylthio, C1-6alkyloxyC1-6alkyl, C1-6alkylthioC1-6alkyl or pyrimidinyl; R6 is hydrogen, halo, polyhaloC1-6alkyl, C1-6alkyl, C1-6alkyloxy, C1-6alkylthio; or two vicinal R6 radicals may be taken together to form a bivalent radical of formula —CH═CH—CH═CH—; r is an integer equal to 1 or 2; R7 is hydrogen, C1-6alkyl, Ar, Het or Het1; provided that the bacterial infection is other than a Mycobacterial infection.

SUBSTITUTED QUINOLINES AND THEIR USE AS MYCOBACTERIAL INHIBITORS

The present invention relates to novel substituted quinoline derivatives according to the general formula (Ia) or the general formula (Ib) salts, quaternary amines, stereochemically isomeric forms, tautomeric forms and N--oxide forms thereof, wherein Rsu

Triazolones as apolipoprotein-B synthesis inhibitors

The present invention concerns novel compounds of formula (I). STR1 wherein R1 is C1-10 alkyl, C3-7 cycloalkyl or C1-6 alkyl substituted with C3-7 cycloalkyl; R2 is hydrogen or C1-6/s