1841081-70-6

Basic information

• Product Name: 3-bromo-6,7-difluoroquinoline
• CAS NO: 1841081-70-6
• Molecular Weight: 244.038
• Mol File: 1841081-70-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-bromo-6,7-difluoroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-6,7-difluoroquinoline(1841081-70-6)
• EPA Substance Registry System: 3-bromo-6,7-difluoroquinoline(1841081-70-6)

Safety Data

• Hazardous Substances Data: 1841081-70-6(Hazardous Substances Data)

Upstream product

• 127827-50-3 6,7-Difluoroquinoline 
• 3863-11-4 3,4-difluoroaniline 

Relevant articles and documents

Synthetic method of 3-amino-6,7-difluoroquinoline

The invention provides a synthetic method of 3-amino-6,7-difluoroquinoline. The synthetic method comprises the following steps: firstly, adding a solvent into glycerol, adding 3,4-difluoroaniline anda catalyst and heating and reacting to obtain 6,7-difluoroquinoline; secondly, slowly adding N-bromosuccinimide and the solvent into the 6,7-difluoroquinoline, heating and reacting to obtain 3-bromo-6,7-difluoroquinoline; thirdly, adding aminomethoxytert-butyl ester, the solvent and the catalyst into the 3-bromo-6,7-difluoroquinoline for reacting to obtain 3-N-t-butoxycarbonylamino-6,7-difluoroquinoline; fourthly, adding hydrochloric acid and the solvent into 3-N-t-butoxycarbonyl amino-6,7-difluoroquinoline for reacting to obtain 3-amino-6,7-difluoroquinoline. The synthetic method of the 3-amino-6,7-difluoroquinoline, disclosed by the invention, has the advantages of simple route, low-priced and easily-obtained raw materials, convenience in post treatment, high product yield and suitability for an enlargement synthetic route of the 3-amino-6,7-difluoroquinoline.