18412-67-4Relevant academic research and scientific papers
Metal-Templated Oligomeric Macrocyclization via Coupling for Metal-Doped π-Systems
Ikemoto, Koki,Isobe, Hiroyuki,Matsuno, Taisuke,Miyachi, Akira,Muto, Hitomi,Sasakawa, Hiroaki,Yang, Seungmin
supporting information, p. 15017 - 15021 (2021/09/30)
A method for the synthesis of metal-doped aromatic macrocycles has been developed. The method, i.e., metal-templated oligomeric macrocyclization via coupling, adopts Ni as the template and assembles five pyridine units via a Ni-mediated coupling reaction
Carbon-based leaving group in substitution reactions: Functionalization of sp3-hybridized quaternary and tertiary benzylic carbon centers
Mahoney, Stuart J.,Lou, Tiantong,Bondarenko, Ganna,Fillion, Eric
, p. 3474 - 3477 (2012/09/05)
Lewis acid promoted substitution reactions employing Meldrum's acid and 5-methyl Meldrum's acid as carbon-based leaving groups are described which transform unstrained quaternary and tertiary benzylic Csp 3-Csp3 bonds into Csp3-X bonds (X = C, H, N). Importantly, this reaction has a broad scope in terms of both suitable substrates and nucleophiles with good to excellent yields obtained (typically >90%).
