184229-63-8

Upstream product

• 6160-65-2 1,1'-Thiocarbonyldiimidazole 
• 184229-62-7 N-(9-{(2R,3R,4S,5R)-4-Benzyloxy-5-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-hydroxy-ethyl]-3-hydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide 
• 184229-60-5 Acetic acid (2R,3R,4R,5R)-2-(6-benzoylamino-purin-9-yl)-4-benzyloxy-5-((R)-1,2-diacetoxy-ethyl)-tetrahydro-furan-3-yl ester 
• 184229-61-6 N-{9-[(2R,3R,4S,5R)-4-Benzyloxy-5-((R)-1,2-dihydroxy-ethyl)-3-hydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 
• 184229-59-2 3-O-benzyl-1,2:5,6-tetra-O-acetyl-β-D-allofuranose 
• 100-39-0 benzyl bromide 
• 22331-21-1 1,2:5,6-di-O-isopropylidene-3-O-benzyl-α-D-allofuranose 
• 14686-89-6 (1,2:5,6)-di-O-isopropylidene-D-gulose 

Downstream Products

• 184229-67-2 N-[9-((2R,4S,5R)-5-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-4-hydroxy-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide 
• 184229-65-0 N-{9-[(2R,4S,5R)-4-Benzyloxy-5-(2-hydroxy-ethyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 
• 184229-66-1 N-{9-[(2R,4S,5R)-4-Hydroxy-5-(2-hydroxy-ethyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 
• 184229-64-9 N-(9-{(2R,4S,5R)-4-Benzyloxy-5-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide 

Relevant academic research and scientific papers

Alteration of DNA primary structure by DNA topoisomerase I. Isolation of the covalent topoisomerase I-DNA binary complex in enzymatically competent form

DNA ligation by DNA topoisomerase I was investigated employing synthetic DNA substrates containing a single strand nick. Site-specific cleavage of the DNA by topoisomerase I in proximity to the nick resulted in uncoupling of the cleavage and ligation reac