184229-72-9

Upstream product

• 958-09-8 2'-deoxy-D-adenosine 
• 184229-70-7 Thioacetic acid S-[(2S,3S,5R)-5-(6-amino-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl] ester 
• 184229-71-8 Benzoic acid (2S,3S,5R)-2-acetylsulfanylmethyl-5-(6-dibenzoylamino-purin-9-yl)-tetrahydro-furan-3-yl ester 

Downstream Products

• 184229-73-0 N-(9-{(2R,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide 
• 184229-74-1 Diisopropyl-phosphoramidous acid (2S,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 

Relevant academic research and scientific papers

Alteration of DNA primary structure by DNA topoisomerase I. Isolation of the covalent topoisomerase I-DNA binary complex in enzymatically competent form

DNA ligation by DNA topoisomerase I was investigated employing synthetic DNA substrates containing a single strand nick. Site-specific cleavage of the DNA by topoisomerase I in proximity to the nick resulted in uncoupling of the cleavage and ligation reac