184291-71-2

Upstream product

• 184292-01-1 (2R,3S,4S)-5-(tert-butyldimethylsiloxy)-3-(4-methoxybenzyloxy)-2,4-dimethylpentanal 
• 184488-77-5 tert-Butyl-[(2S,3R,4S)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-5-enyloxy]-dimethyl-silane 
• 184488-70-8 (2S,3S,4R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-hexan-1-ol 
• 184291-37-0 (3S,4S,5S)-6-(tert-Butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-2-ol 
• 105-13-5 4-Methoxybenzyl alcohol 
• 2746-25-0 p-Methoxybenzyl bromide 
• 184292-12-4 tert-Butyl-[(Z)-(2R,3S,4S)-6-iodo-3-(4-methoxy-benzyloxy)-1,2,4-trimethyl-hex-5-enyloxy]-dimethyl-silane 

Downstream Products

• 184291-74-5 2,2-dimethylpropanoic acid, [2S-(2α(5E,7Z,9S,10S,11R,13R,15Z,17R,18R,20Z,22R),3β,4β,5α,6β)]-18,20-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-23-(4-{[(1,1-dimethylethyl)dimethylsilyl]oxy}tetrahydro-3,5-dimethyl-6-(phenylthio)-2H-pyran-2-yl)-9,11,13, 
• 184291-77-8 C₇₂H₁₂₂O₉SSi₃ 
• 184291-73-4 2,2-Dimethyl-propionic acid (5E,7Z)-(9S,10S,11R)-10-(4-methoxy-benzyloxy)-9,11-dimethyl-12-oxo-trideca-5,7-dienyl ester 

Relevant academic research and scientific papers

Syntheses of discodermolides useful for investigating microtubule binding and stabilization

Discodermolide is a marine natural product reported to inhibit the proliferation of T cells and exhibit immunosuppresive activity. Total syntheses of the natural antipode of discodermolide and several variants are reported. These studies provide reagents