184292-01-1

Upstream product

• 105-13-5 4-Methoxybenzyl alcohol 
• 2746-25-0 p-Methoxybenzyl bromide 
• 475051-45-7 (2R,3S,4S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-2,4-dimethyl-pentanoic acid ethyl ester 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 125244-91-9 3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-methylpropan-1-ol 
• 104701-87-3 3-tert-butyldimethylsilyloxy-2-methylpropanal 
• 374896-36-3 ethyl (2R,3S,4S)-2-bromo-5-(tert-butyldimethylsiloxy)-3-hydroxy-2,4-dimethylpentanoate 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 625109-65-1 (2S,3R,4S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-pentan-1-ol 
• 475143-05-6 ethyl (2R,3S,4S)-5-(tert-butyldimethylsiloxy)-3-(4-methoxybenzyloxy)-2,4-dimethylpentanoate 
• 184488-77-5 tert-Butyl-[(2S,3R,4S)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-5-enyloxy]-dimethyl-silane 

Downstream Products

• 184292-02-2 (4S,5S,6S)-7-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4,6-dimethyl-heptan-3-ol 
• 475143-06-7 ethyl (2R,3S,4R,5S,6S)-2-bromo-7-(tert-butyldimethylsiloxy)-3-hydroxy-5-(4-methoxybenzyloxy)-2,4,6-trimethylheptanoate 
• 184291-74-5 2,2-dimethylpropanoic acid, [2S-(2α(5E,7Z,9S,10S,11R,13R,15Z,17R,18R,20Z,22R),3β,4β,5α,6β)]-18,20-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-23-(4-{[(1,1-dimethylethyl)dimethylsilyl]oxy}tetrahydro-3,5-dimethyl-6-(phenylthio)-2H-pyran-2-yl)-9,11,13, 
• 184291-77-8 C₇₂H₁₂₂O₉SSi₃ 
• 184291-48-3 (3Z,11Z)-(5S,6S,7R,9S,13S,14S,15S)-14-(tert-Butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-5,7,9,11,13,15-hexamethyl-heptadeca-1,3,11,16-tetraen-8-one 

Relevant academic research and scientific papers

Regulated-stereoselective construction of thirteen stereogenic centers necessary for the frame of (+)-discodermolide, based on iterative Lewis acid-promoted aldol reactions

The segments C1-C13 and C15-C 21 containing the 13 stereogenic centers required for the frame of (+)-discodermolide were synthesized in good to excellent enantio- and diastereoselectivities from a common racemic

A short synthesis of the C15-C21 segment of (+)-discodermolide, based on an asymmetric approach from achiral 2-methyl-1,3-propanediol to versatile enantiopure stereotriads

A new approach was developed to versatile enantiopure stereotriads using chiral oxazaborolidinone-promoted asymmetric aldol reaction of a racemic aldehyde with a bromo silyl nucleophile. A short synthesis of the C15-C21 segment of (+

Syntheses of discodermolides useful for investigating microtubule binding and stabilization

Discodermolide is a marine natural product reported to inhibit the proliferation of T cells and exhibit immunosuppresive activity. Total syntheses of the natural antipode of discodermolide and several variants are reported. These studies provide reagents