184291-95-0

Upstream product

• 105-13-5 4-Methoxybenzyl alcohol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 2746-25-0 p-Methoxybenzyl bromide 
• 106296-58-6 (2S,3S,4S)-(1-tert-butyldimethylsilanyloxy)-2,4-dimethylhex-5-en-3-ol 

Downstream Products

• 496035-39-3 (+)-(2S,3S,4S)-5-(tert-butyldimethylsilanyloxy)-3-(4-methoxybenzyloxy)-2,4-dimethylpentan-1-ol 
• 184291-85-8 C₇₄H₁₃₀O₈SSi₄ 
• 184291-48-3 (3Z,11Z)-(5S,6S,7R,9S,13S,14S,15S)-14-(tert-Butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-5,7,9,11,13,15-hexamethyl-heptadeca-1,3,11,16-tetraen-8-one 
• 184291-84-7 (Z)-(8R,9S,10S)-9-(4-Methoxy-benzyloxy)-8,10-dimethyl-1-triethylsilanyloxy-tetradeca-11,13-dien-7-one 
• 184292-25-9 (Z)-(8S,9S,10S)-9-(4-Methoxy-benzyloxy)-8,10-dimethyl-1-triethylsilanyloxy-tetradeca-11,13-dien-7-ol 

Relevant academic research and scientific papers

Synthesis and biological assessment of simplified analogues of the potent microtubule stabilizer (+)-discodermolide

An efficient, convergent and stereocontrolled synthesis of simplified analogues of the potent antimitotic agent (+)-discodermolide has been achieved and several small libraries have been prepared. In all the libraries, the discodermolide methyl groups at

Simultaneous preparation of four truncated analogues of discodermolide by fluorous mixture synthesis

(matrix presented) Four analogues made in one synthesis Four truncated analogues of the natural product discodermolide were synthesized in a single synthetic sequence. Precursors bearing four different groups at C22, each with a unique fluorous p-methoxyb

Syntheses of discodermolides useful for investigating microtubule binding and stabilization

Discodermolide is a marine natural product reported to inhibit the proliferation of T cells and exhibit immunosuppresive activity. Total syntheses of the natural antipode of discodermolide and several variants are reported. These studies provide reagents