184292-02-2

Upstream product

• 925-90-6 ethylmagnesium bromide 
• 184292-01-1 (2R,3S,4S)-5-(tert-butyldimethylsiloxy)-3-(4-methoxybenzyloxy)-2,4-dimethylpentanal 
• 184488-77-5 tert-Butyl-[(2S,3R,4S)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-5-enyloxy]-dimethyl-silane 
• 105-13-5 4-Methoxybenzyl alcohol 
• 2746-25-0 p-Methoxybenzyl bromide 

Downstream Products

• 184488-76-4 (Z)-(4R,5S,6S)-5-(4-Methoxy-benzyloxy)-4,6-dimethyl-deca-7,9-dien-3-one 
• 184488-79-7 (2S,3S,4S)-3-(4-Methoxy-benzyloxy)-2,4-dimethyl-heptane-1,5-diol 

Relevant academic research and scientific papers

Syntheses of discodermolides useful for investigating microtubule binding and stabilization

Discodermolide is a marine natural product reported to inhibit the proliferation of T cells and exhibit immunosuppresive activity. Total syntheses of the natural antipode of discodermolide and several variants are reported. These studies provide reagents