184351-69-7Relevant academic research and scientific papers
A diastereoselective tandem metalloenamine alkylation/aza-annulation of β-tetralones expedites the synthesis of benzoquinolinones
Audia, James E.,Droste, James J.,Dunigan, James M.,Bowers, John,Heath, Perry C.,Holme, Dale W.,Eifert, Jill H.,Kay, Harry A.,Miller, Richard D.,Olivares, Jorge M.,Rainey, Thomas F.,Weigel, Leland O.
, p. 4121 - 4124 (2007/10/03)
In one operation, metalloenamines derived from R-phenylethylamine (PEA) and a β-tetralone were treated with an electrophile followed by acrylic anhydride. The unpurified lactams were reduced to give 10b-angular benzoquinolinones (BQs).
