29419-15-6

Basic information

• Product Name: 5-Fluoro-2-tetralone
• Synonyms: 5-Fluoro-3,4-dihydronaphthalen-2(1H)-one;5-Fluoro-2-tetralone;Zinc04202736;7-fluoro-3;7-fluoro-1,2,3,4-tetrahydronaphthalen-2-one;2(1H)-Naphthalenone, 7-fluoro-3,4-dihydro-;7-fluoro-3,4-dihydronaphthalen-2(1H)-one;7-Fluoro-3,4-dihydro-2(1H)-naphthalenone
• CAS NO: 29419-15-6
• Molecular Formula: C₁₀H₉FO
• Molecular Weight: 164.18
• Mol File: 29419-15-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 265.5 °C at 760 mmHg
• Flash Point: 101.4 °C
• Appearance: /
• Density: 1.199 g/cm³
• Vapor Pressure: 0.00911mmHg at 25°C
• Refractive Index: 1.542
• CAS DataBase Reference: 5-Fluoro-2-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluoro-2-tetralone(29419-15-6)
• EPA Substance Registry System: 5-Fluoro-2-tetralone(29419-15-6)

Safety Data

• Hazardous Substances Data: 29419-15-6(Hazardous Substances Data)

Usage

General Description

5-Fluoro-2-tetralone is a chemical compound with the molecular formula C10H9FO. It is a fluoro-substituted derivative of tetralone, a bicyclic compound. 5-Fluoro-2-tetralone is used as an intermediate in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It is also employed in research and development as a building block for creating new compounds with potential medicinal or agricultural properties. The fluoro substitution in 5-Fluoro-2-tetralone makes it a valuable tool for medicinal chemistry due to its ability to alter the physicochemical and biological properties of the parent compounds.

InChI:InChI=1/C10H9FO/c11-9-3-1-7-2-4-10(12)6-8(7)5-9/h1,3,5H,2,4,6H2

Upstream product

• 74-85-1 ethene 
• 458-04-8 3-fluorophenylacetyl chloride 
• 589-06-0 4-(4-fluorophenyl)butanoic acid 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 
• 352-70-5 m-Fluorotoluene 
• 501-00-8 3-fluorophenylacetonitrile 
• 331-25-9 (3-fluorophenyl)acetic acid 

Downstream Products

• 184351-69-7 (7-Fluoro-1-methyl-3,4-dihydro-naphthalen-2-yl)-((R)-1-phenyl-ethyl)-amine 
• 184351-67-5 (7-Fluoro-3,4-dihydro-naphthalen-2-yl)-((R)-1-phenyl-ethyl)-amine 
• 889884-94-0 7-fluoronaphthalen-2-ol 

Relevant articles and documents

FUSED IMIDAZOLE DERIVATIVE

According to the present invention, fused imidazole derivatives of the general formula: wherein R1 is a hydrogen atom, a halogen atom, hydroxy group, a lower alkyl group or a lower alkoxy group, R2 is an aryl group, benzodioxanyl group, or 5-6 membered, monocyclic, unsaturated, heterocyclic group containing nitrogen atom(s) which may be substituted with lower alkyl, trityl or oxo, R3 is a hydrogen atom or hydroxy group, A is a group represented by the formula : -(CH2)m - or -O-(CH2)m- [wherein m is an integer of 1-3] and their salts are provided.

Benzoquinazoline inhibitors of thymidylate synthase: Enzyme inhibitory activity and cytotoxicity of some 3-amino- and 3-methylbenzo[f]quinazolin- 1(2H)-ones

The synthesis and thymidylate synthase (TS) inhibitory activity of a series of simple benzo[f]-quinazolin-1(2H)-ones are described. Fully aromatic 3-amino compounds with compact lipophilic substituents in the 9-position were found to have I50 values as low as 20 nM on the isolated enzyme, and represent the first examples of potent, folate-based TS inhibitors that completely lack any structural feature corresponding to the (p- aminobenzoyl)glutamate moiety of the cofactor. A number of the compounds also showed moderate growth inhibitory activity against a human colon adenocarcinoma cell line (SW480), with IC50 values as low as 2 μM.