18436-89-0

Upstream product

• 18436-83-4 1,3,3-trimethyl-4-piperidinone 
• 591-51-5 phenyllithium 

Downstream Products

• 98854-98-9 (-)-1,3,3-trimethyl-4-phenyl-4-piperidinol 
• 99156-44-2 4-phenyl-1,3,3-trimethyl-1,2,3,6-tetrahydropyridine 
• 98855-00-6 (+)-1,3,3-trimethyl-4-phenyl-4-piperidinol 

Relevant academic research and scientific papers

Racemic and optically active 1,3,3-trimethyl-4-phenyl-4-(propionyloxy)piperidine

The preparation and resolution of 1,3,3-trimethyl-4-phenyl-4-(propionyloxy)piperidine (5,3-methylprodine) are described, and the results of the antinociceptive activities of the products by hot-plate (mice) and tail-withdrawal (rats) tests are shown to su

Synthesis and toxicity toward nigrostriatal dopamine neurons of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) analogues

Six compounds having structural features in common with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were synthesized and tested in mice for the ability to produce a prolonged decrease in nigrostriatal dopamine (DA) and DA metabolites. The compounds that were prepared and tested include the ester elimination products of the analgetic drugs α-prodine and trimeperidine. None of the compounds in this study, except for MPTP, produced significant neurotoxic effects in the mouse model. The study shows that minor changes in the tetrahydropyridine ring of MPTP result in a marked decrease in neurotoxicity.