99156-44-2 Usage
Structural Similarity
To the neurotransmitter dopamine
Notoriety
As a neurotoxin
Target
Selectively damages dopaminergic neurons in the brain
Symptoms
Leads to symptoms similar to Parkinson's disease
Usage
Frequently used in laboratory research to induce Parkinson's-like symptoms in animal models
Purpose
To study the disease and develop potential treatments
Implication
In cases of drug abuse
Conversion
Can be converted into the toxic compound MPP+ in the body
Result of Conversion
Leads to severe neurological damage
Regulation
Tightly regulated due to its potential for harm
Safety
Not considered safe for human use
Check Digit Verification of cas no
The CAS Registry Mumber 99156-44-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,1,5 and 6 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 99156-44:
(7*9)+(6*9)+(5*1)+(4*5)+(3*6)+(2*4)+(1*4)=172
172 % 10 = 2
So 99156-44-2 is a valid CAS Registry Number.
InChI:InChI=1/C14H19N/c1-14(2)11-15(3)10-9-13(14)12-7-5-4-6-8-12/h4-9H,10-11H2,1-3H3
99156-44-2Relevant academic research and scientific papers
Synthesis and toxicity toward nigrostriatal dopamine neurons of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) analogues
Fries,De Vries,Hazelhoff,Horn
, p. 424 - 427 (2007/10/02)
Six compounds having structural features in common with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were synthesized and tested in mice for the ability to produce a prolonged decrease in nigrostriatal dopamine (DA) and DA metabolites. The compounds that were prepared and tested include the ester elimination products of the analgetic drugs α-prodine and trimeperidine. None of the compounds in this study, except for MPTP, produced significant neurotoxic effects in the mouse model. The study shows that minor changes in the tetrahydropyridine ring of MPTP result in a marked decrease in neurotoxicity.
