184414-29-7

Upstream product

• 186581-53-3 diazomethane 
• 56539-85-6 α-(trifluoromethyl)-phenylacetic acid 
• 1979-51-7 1,1,3,3,3-pentafluoro-2-phenylpropene 
• 124-41-4 sodium methylate 
• 434-45-7 2,2,2-Trifluoroacetophenone 
• 22979-35-7 Methyl phenyldiazoacetate 
• 147531-11-1 trifluoromethanesulfonic acid diphenyl(trifluoromethyl)sulfonium salt 
• 101-41-7 benzeneacetic acid methyl ester 
• 56135-01-4 methyl 3,3-difluoro-2-phenylacrylate 
• 837429-67-1 α-(trifluoromethyl)-β-methoxystyrene 
• 78659-23-1 3,3,3-trifluoro-2-phenylpropionaldehyde 

Relevant academic research and scientific papers

F--Free Deoxyhydrotrifluoromethylation of α-Keto Esters with Ph3P+CF2CO2-: Synthesis of α-CF3-Substituted Esters

Trifluoromethylated compounds are usually obtained via trifluoromethylation reaction by the use of CF3SiMe3 and NaSO2CF3, Umemoto's and Togni's reagents. Here, an external fluorine anion-free direct deoxyhydrotrifluoromethylation of α-keto esters with a d

Cu-Mediated Trifluoromethylation of Aromatic α-Diazo Esters with the Yagupolskii–Umemoto Reagent

Reductive trifluoromethylation of aromatic α-diazo esters at room temperature with the Yagupolskii–Umemoto reagent {[Ph2SCF3][OTf]; (2a)} in DMF in the presence of excess CuCl gave a variety of α-trifluoromethyl arylacetates in up to

Efficient one step procedure for the synthesis of α- trifluoromethylated arylacetates

The reaction of β,β-difluoro-α-trifluoromethylstyrene derivatives 1 with 3 equiv. of sodium methoxide in acetonitrile at 25°C afforded a- trifluoromethylated arylacetates 3 in good yields.

Effect of fluorine substitution of α-and β-hydrogen atoms in ethyl phenylacetate and phenylpropionate on their stereoselective hydrolysis by cultured cancer cells

(±)-Ethyl 2-fluoro-2-phenylacetate was stereoselectively hydrolyzed by cultured cells of several rat cancer cell lines to give the carboxylic acid rich in the R enantiomer. The stereoselectivity increased for (±)-ethyl 2-fluoro-2-phenylpropionate (2b) with all present cell lines and for (±)-ethyl 2-phenyl-3,3,3-trifluoropropionate (3b) with rat hepatoma McA-RH7777 cell line. The stereoselectivity was different for the different cell lines, as McA-RH7777 cells preferred (R)-2b in contrast with the preference towards (S)-2b by other cells such as ras oncogene-transformed rat liver Anr4 cells. These stereoselectivities were different from those for non-fluorinated (±)-ethyl 2-phenylpropionate. Thus fluorine atoms are recognized by ester hydrolases of cancer cells, and fluorine substitution on the acyl group will be useful for making ester-type anticancer prodrugs more specific to cancer cells.