184473-59-4

Upstream product

• 446831-24-9 1-bromo-4-chloromethyl-2,5-dimethoxy-benzene 
• 143-33-9 sodium cyanide 
• 1758-25-4 (2,5-dimethoxyphenyl)acetic acid 
• 25245-34-5 1-bromo-2,5-dimethoxybenzene 

Downstream Products

• 1758-25-4 (2,5-dimethoxyphenyl)acetic acid 
• 184473-60-7 2-(4-bromo-2,5-dimethoxyphenyl)ethanol 
• 40492-53-3 2,3-dihydro-6-bromo-5-hydroxybenzofuran 
• 184473-61-8 2,5-dihydroxy-4-bromophenethylbromide 

Relevant academic research and scientific papers

One-pot Claisen rearrangement/O-methylation/alkene isomerization in the synthesis of ortho-methoxylated phenylisopropylamines

An improved synthesis of a potent serotonin agonist 1a and its novel derivative 1b is described, making use of a Claisen rearrangement whose unstable phenolic product is methylated and isomerized in situ. This method may be of general use in the synthesis of α-methoxylated phenethylamine derivatives. The synthesis also includes an unusual, one pot demethylation/primary alcohol bromination with boron tribromide.

NOVEL BENZOPYRAN ANALOGS AND THEIR USE FOR THE TREATMENT OF GLAUCOMA

Novel benzopyran analogs are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of