184485-50-5

Upstream product

• 61950-54-7 (8aS)-1,1-(1,2-ethylenedioxy)-1,2,3,4,6,7,8,8a-octahydro-8a-methyl-6-oxonaphthalene 
• 184485-48-1 (1S,2S,4aS)-(-)-trans-1α-[(2,5-dimethoxyphenyl)methyl]-5-(2-methyl-1,3-dioxolan-2-yl)-octahydro-1β,2β,4aβ-trimethyl-5(6H)-naphthalenone 
• 19493-09-5 Methylenetriphenylphosphorane 
• 184485-49-2 (-)-(1R,4aS,8aS)-1β,2β,4aβ-trimethyl-1α-[(2',5'-dimethoyphenyl)methyl]-1,2,3,4,4a,5,6,7,8,8aα-decahydronaphthalen-5-one 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 184485-46-9 (1S,4aS)-(+)-trans-1α-[(2,5-dimethoxyphenyl)methyl]-1β,4aβ-dimethyl-5-(2-methyl-1,3-dioxolan-2-yl)-hexahydro-2,5(3H,6H)-naphthalenedione 
• 184485-47-0 (1S,4aS)-(+)-trans-1α-[(2,5-dimethoxyphenyl)methyl]-1β,4aβ-dimethyl-5-(2-methyl-1,3-dioxolan-2-yl)-2-methyleneoctahydro-5(6H)-naphthalenone 
• 274900-31-1 (4aS,5S,8aS)-5-(2,5-Dimethoxy-benzyl)-5,8a-dimethyl-6-methylene-octahydro-naphthalen-1-one 
• 41722-49-0 (S)-1,4a-dimethyl-4,4a,7,8-tetrahydronaphthalene-2,5(3H,6H)-dione 
• 60732-17-4 2,5-dimethoxybenzyl bromide 
• 33524-31-1 2,5-dimethoxybenzyl alcohol 
• 26742-33-6 (4aS)-1,4aβ-dimethyl-4,4a,7,8-tetrahydronaphthalene-2,5(3H,6H)-dione-5-ethyeneacetal 

Downstream Products

• 129445-46-1 2-[[(1R,2S,4aS,8aS)-1,2,4a-trimethyl-5-(methylene)decahydronaphthalen-1-yl]methyl]cyclohexa-2,5-diene-1,4-dione 
• 55303-98-5 avarol 
• 55303-99-6 avarone 
• 61187-42-6 avarol dimethyl ether 

Relevant academic research and scientific papers

NOVEL USE OF SESQUITERPENE DERIVATIVE

The present disclosure relates to a novel use of a sesquiterpene derivative, more particularly to a composition for preventing, improving or treating macular degeneration or macular edema caused by vascular leakage in the eye, the composition containing a

New tools for studying vesicular-mediated protein trafficking: Synthesis and evaluation of ilimaquinone analogs in a non-radioisotope-based antisecretory assay

Structural variants of the marine sponge metabolite ilimaquinone, with comparable biological activity, have been prepared. These analogs, as well as related natural products, were screened for their effects on the Golgi apparatus through a novel, non-radioisotope-based secretion assay. The assay has identified a variant of ilimaquinone that contains a versatile linker group yet retains the natural product's cellular activity. This functional ilimaquinone analog will be a valuable tool for studying intracellular protein trafficking.

Enantiospecific total synthesis of (+)- and (-)-avarone and -avarol

Enantiopure avarol and its oxidized congener avarone are synthesized in both podal series from an optically pure Wieland-Miescher enone; preliminary results from biochemical studies are summarized.

Stereoselective synthesis of (+)-avarol, (+)-avarone, and some nonracemic analogues

Synthesis of the rearranged drimane sesquiterpenoids (+)-avarol and (+)-avarone from Wieland-Miescher ketone is described. This synthetic sequence provides convenient access to the natural enantiomers and, based on comparison of the optical rotation of synthetic avarol dimethyl ether with literature data, affords material of significantly higher optical rotation than a natural source. Similar synthetic strategies have been used to obtain several related compounds, including a decalin bearing an exocyclic olefin and a highly substituted cyclohexane, that can be viewed as hybrids of the trans-fused avarol and cis-fused arenarol skeletons.