18451-46-2Relevant academic research and scientific papers
(E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent
Horley, Neill J.,Beresford, Kenneth J.M.,Kaduskar, Supriya,Joshi, Prashant,McCann, Glen J.P.,Ruparelia, Ketan C.,Williams, Ibidapo S.,Gatchie, Linda,Sonawane, Vinay R.,Bharate, Sandip B.,Chaudhuri, Bhabatosh
, p. 5409 - 5414 (2017)
The overexpression of CYP1 family of enzymes is reported to be associated with development of human carcinomas. It has been well reported that CYP1A1 specific inhibitors prevents carcinogenesis. Herein, thirteen pyridine-4-yl series of chalcones were synt
Synthesis, biological activities of chalcones and novel 4-acetylpyridine oximes, molecular docking of the synthesized products as acetylcholinesterase ligands
Behr, Jean-Bernard,Benazzouz-Touami, Amina,Machado-Rodrigues, Carine,Makhloufi-Chebli, Malika,Ould Lamara, Kamilia,Robert, Anthony,Terrachet-Bouaziz, Souhila
, (2021/12/22)
Heterocyclic chalcones were synthesized by reaction of 4-acetylpyridine with the corresponding aromatic aldehydes under Claisen Schmidt conditions. These chalcones were used as starting material for the synthesis of oximes in the presence of hydroxylamine
Synthesis of 2,4,6-trisubstituted pyrimidine and triazine heterocycles as antileishmanial agents
Sunduru, Naresh,Agarwal, Anu,Katiyar, Sanjay Babu,Nishi,Goyal, Neena,Gupta, Suman,Chauhan, Prem M.S.
, p. 7706 - 7715 (2007/10/03)
A series of 2,4,6 trisubstituted pyrimidines and triazines have been synthesized and screened for its in vitro antileishmanial activity profile in promastigote model. Nine compounds have shown >94% inhibition against promastigotes at a concentration of 10
Synthesis of 2,4,6-trisubstituted pyrimidines as antimalarial agents
Agarwal, Anu,Srivastava, Kumkum,Puri,Chauhan, Prem M. S.
, p. 4645 - 4650 (2007/10/03)
A series of 2,4,6-trisubstituted-pyrimidines were synthesized and evaluated for their in vitro antimalarial activity against Plasmodium falciparum. Of the 18 compounds synthesized, 14 compounds have shown MIC in the range of 0.25-2 μg/mL. These compounds
Antimalarial activity of 2,4,6-trisubstituted pyrimidines
Agarwal, Anu,Srivastava, Kumkum,Puri,Chauhan, Prem M. S.
, p. 1881 - 1883 (2007/10/03)
A series of 2,4,6-trisubstituted pyrimidines (3a-o) was synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 15 compounds synthesized 11 compounds showed MIC in the range of 0.5-2 μg/mL. These compounds are
Antimalarial activity and synthesis of new trisubstituted pyrimidines
Agarwal, Anu,Srivastava, Kumkum,Puri,Chauhan, Prem M.S.
, p. 3130 - 3132 (2007/10/03)
A series of 2,4,6-trisubstituted-pyrimidines was synthesized and evaluated for their in vitro antimalarial activity against Plasmodium falciparum. Out of the 30 compounds synthesized 21 compounds showed MIC in the range of 0.5-2 μg/mL. These compounds are
Synthesis and activity of a new series of chalcones as aldose reductase inhibitors
Severi, Fabio,Benvenuti, Stefania,Costantino, Luca,Vampa, Gabriella,Melegari, Michele,Antolini, Luciano
, p. 859 - 866 (2007/10/03)
A new series of chalcone derivatives has been synthesized and tested in vitro in order to assess their ability to inhibit aldose reductase enzyme (ALR2) and their specificity towards the target enzyme with respect to other oxidoreductases, such as aldehyde reductase, sorbitol dehydrogenase, and glutathione reductase. All the compounds display affinity for ALR2. The X-ray crystal structure of 1-(2,4-dihydroxyphenyl)-3-(2-methoxyphenyl)propen-1-one was determined.
