184528-50-5

Upstream product

• 79027-28-4 (2S)-3-(benzyloxy)-2-methylpropanal 
• 136314-66-4 methyl (3S,4E)-3-(dimethylphenylsilyl)-4-hexenoate 

Downstream Products

• 444109-34-6 Isobutyric acid (Z)-(1S,4S,5R,6S)-5-(tert-butyl-dimethyl-silanyloxy)-1-{(2S,3S)-2-hydroxy-3-[(2S,4R,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-butyl}-4,6-dimethyl-8-trimethylsilanyl-non-7-en-2-ynyl ester 
• 444109-38-0 (R)-2-[(2R,4S,5S,6S)-6-[(Z)-(2S,5S,6R,7S)-6-(tert-Butyl-dimethyl-silanyloxy)-2-methoxymethoxy-5,7-dimethyl-9-trimethylsilanyl-dec-8-en-3-ynyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propionic acid methyl ester 
• 444109-40-4 (R)-2-[(2R,4S,5S,6S)-6-[(3Z,8Z)-(2S,5S,6S,7S)-6-(tert-Butyl-dimethyl-silanyloxy)-2-methoxymethoxy-5,7-dimethyl-9-trimethylsilanyl-deca-3,8-dienyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propionic acid methyl ester 
• 444109-45-9 (R)-2-[(2R,4S,5S,6S)-6-[(Z)-(2S,5S,6R,7S)-6-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-5,7-dimethyl-9-trimethylsilanyl-dec-8-en-3-ynyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propionic acid 
• 444109-37-9 (R)-2-[(2R,4S,5S,6S)-6-[(Z)-(2S,5S,6R,7S)-6-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-5,7-dimethyl-9-trimethylsilanyl-dec-8-en-3-ynyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propionic acid methyl ester 
• 444109-35-7 (Z)-(2S,5S,6R,7S)-6-(tert-Butyl-dimethyl-silanyloxy)-1-[(2R,4S,5S,6R)-6-((S)-2-hydroxy-1-methyl-ethyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-5,7-dimethyl-9-trimethylsilanyl-dec-8-en-3-yn-2-ol 
• 444109-33-5 (Z)-(2R,5S,8S,9R,10S)-9-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-2-[(2S,4R,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-8,10-dimethyl-12-trimethylsilanyl-tridec-11-en-6-yn-3-one 
• 444109-36-8 (Z)-(2S,3S,5S,8S,9R,10S)-9-(tert-Butyl-dimethyl-silanyloxy)-2-[(2S,4R,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-8,10-dimethyl-12-trimethylsilanyl-tridec-11-en-6-yne-3,5-diol 
• 444109-44-8 (R)-2-[(2R,4S,5S,6S)-6-[(Z)-(2S,5S,6R,7S)-6-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-5,7-dimethyl-9-trimethylsilanyl-dec-8-en-3-ynyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propionaldehyde 
• 444109-27-7 (2S,3R,4S)-1-benzyloxy-3-(tert-butyldimethylsilanyloxy)-6,6-dibromo-2,4-dimethyl-hex-5-ene 
• 444109-42-6 (2S,3R,4S)-5-benzyloxy-3-(tert-butyldimethylsilyloxy)-2,4-dimethyl-pentanal 
• 444109-29-9 (1E,3S,4R,5S)-6-benzyloxy-4-(tert-butyldimethylsilanyloxy)-3,5-dimethyl-1-iodo-1-trimethylsilanyl-hex-1-ene 
• 444109-30-2 (2Z,4S,5R,6S)-7-benzyloxy-5-(tert-butyldimethylsilanyloxy)-4,6-dimethyl-2-trimethylsilanyl-hept-2-ene 
• 444109-28-8 (3S,4R,5S)-6-benzyloxy-4-(tert-butyldimethylsilanyloxy)-3,5-dimethyltrimethylsilanylhex-1-yne 

Relevant academic research and scientific papers

Studies directed toward the total synthesis of discodermolide: asymmetric synthesis of the C1-C14 fragment.

[structure: see text] A convergent and stereoselective assembly of the C1-C14 subunit of marine natural product (+)-discodermolide has been completed. The approach employs chiral allylsilane bond construction methodology to establish four of the eight ste

Crotylsilane reagents in the synthesis of complex polyketide natural products: Total synthesis of (+)-discodermolide

An efficient, highly convergent stereocontrolled synthesis of (+)-discodermolide has been achieved with 2.1% overall yield (27 steps longest linear sequence). The absolute stereochemistry of the C1-C6 (12), C7-C14 (13), and C15-C24 (11) subunits was intro