184534-61-0

Basic information

• Product Name: 1H-Pyrazol-5-ol, 4-[1H-indol-3-yl(4-nitrophenyl)methyl]-3-methyl-1-phenyl-
• CAS NO: 184534-61-0
• Molecular Formula: C25H20N4O3
• Molecular Weight: 424.459
• Mol File: 184534-61-0.mol

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazol-5-ol, 4-[1H-indol-3-yl(4-nitrophenyl)methyl]-3-methyl-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazol-5-ol, 4-[1H-indol-3-yl(4-nitrophenyl)methyl]-3-methyl-1-phenyl-(184534-61-0)
• EPA Substance Registry System: 1H-Pyrazol-5-ol, 4-[1H-indol-3-yl(4-nitrophenyl)methyl]-3-methyl-1-phenyl-(184534-61-0)

Safety Data

• Hazardous Substances Data: 184534-61-0(Hazardous Substances Data)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 942-32-5 5-methyl-2-phenyl-2H-pyrazol-3-ol 
• 120-72-9 indole 
• 89-25-8 edaravone 
• 132603-48-6 E-1-phenyl-3-methyl-4-<(4-nitrophenyl)methylene>-5-pyrazolone 

Downstream Products

• 132603-48-6 E-1-phenyl-3-methyl-4-<(4-nitrophenyl)methylene>-5-pyrazolone 

Relevant articles and documents

One-pot sequential multi-component reaction: Synthesis of 3-substituted indoles

Here, we have developed a 3-component one-pot sequential approach to 3-substituted indoles. The main advantages of this process are step economy, reduced waste, and operational simplicity. The method involves in situ generation of 3-indolylalcohols from t

Hydrogen-Bond-Catalyzed Arylation of 3-(Aminoalkyl)indoles via C-N Bond Cleavage with Thiourea under Microwave Irradiation: An Approach to 3-(α,α-Diarylmethyl)indoles

We have developed a simple and efficient method for the arylation of 3-(aminoalkyl)indoles with aryl alcohols and other aromatic nucleophiles through C-N bond cleavage under microwave irradiation to synthesize 3-(α,α-diarylmethyl)indoles. The method uses thiourea as catalyst, which is environmentally benign, water-tolerant and easy to handle. Notably, acid-sensitive substrates are tolerated under the reaction conditions. Thiourea activates the tertiary amine through double hydrogen bonding and converts it into a better leaving group. The reaction proceeds through the formation of vinylogous iminium ion as an intermediate.

Solid-state synthesis of 4-[(indol-3-yl)-arylmethyl]-1-phenyl-3-methyl-5- pyrazolones by catalysis of molecular iodine

4-[(Indol-3-yl)-arylmethyl]-1-phenyl-3-methyl-5-pyrazolones could be smoothly and effectively obtained in good yields through the iodine-catalyzed reactions under solid-state conditions at room tempertaure. The three-component approach in a one-pot proced

The solid-state Michael addition of indole to 4-arylidene-3-methyl-5- pyrazolone

The Michael addition reactions of indole to 4-arylidene-3-methyl-1- phenyl-5-pyrazolone 1 were investigated in the solid state, by which a series of new compounds, 1-aryl-1-(3-indolyl)-1-(3'-methyl-1'-phenyl-5'-pyrazolon- 4'-yl)methanes 2, were easily obtained. This provides a feasible method of preparing novel compounds containing two heterocyclic groups at the same carbon.