18455-98-6

Basic information

• Product Name: Fukinolide
• Synonyms: Fukinolide;(-)-Bakkenolide B;(1'R,3R,7'aβ)-1'β-Acetoxy-3'aβ,4'β-dimethyl-4-methylene-7'α-[[(2Z)-2-methyl-2-butenoyl]oxy]spiro[oxolane-3,2'-hydrindane]-2-one;(Z)-2-Methyl-2-butenoic acid [(3R,3'aα)-3'α-acetoxy-4,5,1',3',3'a,4',5',6',7',7'a-decahydro-7'α,7'aα-dimethyl-4-methylene-2-oxospiro[furan-3(2H),2'-[2H]inden]-4'β-yl] ester;Bakkenolide B
• CAS NO: 18455-98-6
• Molecular Formula: C22H30O6
• Molecular Weight: 390.47
• Mol File: 18455-98-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Fukinolide(CAS DataBase Reference)
• NIST Chemistry Reference: Fukinolide(18455-98-6)
• EPA Substance Registry System: Fukinolide(18455-98-6)

Safety Data

• Hazardous Substances Data: 18455-98-6(Hazardous Substances Data)

Usage

General Description

Fukinolide is a natural product compound that has been isolated from the fungus Fukang fungus. It belongs to the class of organic compounds known as sesquiterpenoids and has demonstrated potent anti-inflammatory and anti-cancer properties in various studies. Fukinolide has been found to inhibit the production of inflammatory cytokines and reduce the growth and proliferation of cancer cells. Its unique chemical structure and biological activities have made it a promising candidate for further research and potential development as a pharmaceutical agent for treating inflammatory and cancer-related conditions.

Upstream product

• 322479-99-2 C₁₅H₂₀O₄ 
• 322480-03-5 C₁₅H₁₈O₄ 
• 322726-32-9 (+)-1α,9β-dihydroxy-7-epi-bakkenolide A 
• 322480-02-4 (+)-1,10-didehydro-7-epi-9α-hydroxy-bakkenolide A 
• 192197-74-3 (2'S,3a'R,4'S,7a'S)-3a',4'-dimethyl-4-methyleneoctahydro-2H-spiro[furan-3,2'-indene]-1',2-(3'H)-dione 
• 322479-98-1 (-)-1,10-didehydro-7-epi-9-oxo-bakkenolide A 
• 192197-73-2 (1S,2R,6S,8S)-ethyl-1,2-dimethyl-7-oxobicyclo[4.3.0]nonane-8-carboxylate 
• 322480-00-2 (2S,3aR,4S,7aS)-prop-2-ynyl 3a,4-dimethyl-1-oxooctahydro-1H-indene-2-carboxylate 
• 18456-00-3 (-)-Bakkenolide C 
• 108-24-7 acetic anhydride 
• 1121-18-2 2-methyl-2-cyclohexen-1-one 
• 24909-95-3 (-)-Bakkenolide III 
• 565-63-9 Angelic acid 
• 137601-32-2 (2Z)-2-methyl-2-butenoic 2,4,6-trichlorobenzoic anhydride 

Relevant articles and documents

First comprehensive bakkane approach: Stereoselective and efficient dichloroketene-based total syntheses of (±)- and (-)-9-acetoxyfukinanolide, (±)- and (+)-bakkenolide a, (-)-bakkenolides III, B, C, H, L, V, and X, (±)- and (-)-homogynolide A, (±)-homogynolide B, and (±)-palmosalide C

Cycloaddition of dichloroketene with dimethylcyclohexenes has been used as the key reaction in an efficient, general approach to the bakkanes. New methods and methodologies that have been developed in this work include spiro β-methylene-γ-butyrolactonizations, a vicinal dicarboxylation, an angelic ester preparation, a transesterification, an epoxy ketone double reduction, and a retro aldol-aldol approach to low-energy aldol isomers.