18455-98-6

Usage

Uses

Used in Pharmaceutical Industry:
Fukinolide is used as an anti-inflammatory agent for its ability to inhibit the production of inflammatory cytokines, which can help in managing inflammatory conditions.
Fukinolide is also used as an anti-cancer agent for its ability to reduce the growth and proliferation of cancer cells, offering potential therapeutic benefits in cancer treatment.
These applications highlight the versatility of Fukinolide in addressing both inflammatory and cancer-related conditions, showcasing its potential as a valuable compound in the pharmaceutical industry.

Upstream product

• 18456-00-3 (-)-Bakkenolide C 
• 108-24-7 acetic anhydride 
• 565-63-9 Angelic acid 
• 6610-16-8 (R)-(+)-2-methyl-2-cyclohexen-1-ol 
• 137601-32-2 (2Z)-2-methyl-2-butenoic 2,4,6-trichlorobenzoic anhydride 
• 122518-91-6 (S)-1,6-dimethyl-1-cyclohexene 
• 122452-76-0 Phenyl-carbamic acid (R)-2-methyl-cyclohex-2-enyl ester 
• 122518-90-5 (1R,2S,6S)-8,8-Dichloro-1,2-dimethyl-bicyclo[4.2.0]octan-7-one 
• 1121-18-2 2-methyl-2-cyclohexen-1-one 
• 24909-95-3 (-)-Bakkenolide III 
• 322480-00-2 (2S,3aR,4S,7aS)-prop-2-ynyl 3a,4-dimethyl-1-oxooctahydro-1H-indene-2-carboxylate 
• 322479-99-2 C₁₅H₂₀O₄ 
• 322480-03-5 C₁₅H₁₈O₄ 
• 322726-32-9 (+)-1α,9β-dihydroxy-7-epi-bakkenolide A 

Relevant academic research and scientific papers

First comprehensive bakkane approach: Stereoselective and efficient dichloroketene-based total syntheses of (±)- and (-)-9-acetoxyfukinanolide, (±)- and (+)-bakkenolide a, (-)-bakkenolides III, B, C, H, L, V, and X, (±)- and (-)-homogynolide A, (±)-homogynolide B, and (±)-palmosalide C

Cycloaddition of dichloroketene with dimethylcyclohexenes has been used as the key reaction in an efficient, general approach to the bakkanes. New methods and methodologies that have been developed in this work include spiro β-methylene-γ-butyrolactonizations, a vicinal dicarboxylation, an angelic ester preparation, a transesterification, an epoxy ketone double reduction, and a retro aldol-aldol approach to low-energy aldol isomers.

The first entry to complex bakkanes: A highly effective retroaldol-aldol-based approach to (-)-bakkenolides III B, C, and H

A novel SmI2-promoted chemoselective double reduction of an epoxy ketone and a thermodynamically governed retroaldol-aldol reaction have allowed the first successful entry to enantio-pure (-)-bekkenolide III (1) to be realized. This compound ha