184577-92-2Relevant academic research and scientific papers
Enantioselective synthesis of α-aminosilanes by copper-catalyzed hydroamination of vinylsilanes
Niljianskul, Nootaree,Zhu, Shaolin,Buchwald, Stephen L.
, p. 1638 - 1641 (2015/02/05)
The synthesis of α-aminosilanes by a highly enantio- and regioselective copper-catalyzed hydroamination of vinylsilanes is reported. The system employs Cu-DTBM-SEGPHOS as the catalyst, diethoxymethylsilane as the stoichiometric reductant, and O-benzoylhyd
Vinyldimethylphenylsilanes as safety catch silanols in fluoride-free palladium-catalyzed cross-coupling reactions
Anderson, James C.,Munday, Rachel H.
, p. 8971 - 8974 (2007/10/03)
A series of five structurally diverse vinyldimethylphenylsilanes have been shown to undergo a fluoride-free one-pot palladium-catalyzed cross-coupling reaction with phenyl iodide to give ipso coupled products in 62-86% yield. The limitations of this present protocol lie in the activation of Si-Ph vs protodesilylation by KOTMS/18-C-6, which seems sensitive to the sterics of cis substituents, but not geminal substituents.
General method for preparation of allenic zinc reagents by three-carbon homologation of triorganozincates: Convergent three-component coupling of propargylic substrates, triorganozincates, and electrophilic reagents
Harada, Toshiro,Katsuhira, Takeshi,Osada, Atsushi,Iwazaki, Katsuhiro,Maejima, Keiji,Oku, Akira
, p. 11377 - 11390 (2007/10/03)
Allenic zinc reagents (R1R2C=C=C(R3)ZnL) are efficiently prepared by the reaction of propargylic substrates (R1R2C(X)C≡CH, X = MeSO2O,Cl, R2NCO2) with a variety of tri
