18458-50-9Relevant articles and documents
Stereoselective synthesis of MaR2n-3 DPA
S?nderskov, Jeanne,Tungen, J?rn E.,Palmas, Francesco,Dalli, Jesmond,Serhan, Charles N.,Stenstr?m, Yngve,Vidar Hansen, Trond
, (2019/12/24)
The first total synthesis of the n-3 docosapentaenoic derived oxygenated product MaR2n-3 DPA has been achieved. The 13R and 14S stereogenic centers were introduced using 2-deoxy-D-ribose in a chiral pool strategy. The geometry of the Z,E,E-triene moiety was prepared using highly E-selective Wittig- and Takai-olefination reactions as well as the Z-stereoselective Lindlar reduction. LC/MS-MS data of synthetic MaR2n-3 DPA matched data for the biosynthetic formed product that enabled the configurational assignment of this oxygenated natural product to be (7Z,9E,11E,13R,14S,16Z,19Z)-13,14-dihydroxydocosa-7,9,11,16,19-pentaenoic acid.