2536-36-9

Basic information

• Product Name: IHDA
• Synonyms: Hexadecanoic acid, 16-iodo-;IHDA
• CAS NO: 2536-36-9
• Molecular Formula: C₁₆H₃₁IO₂
• Molecular Weight: 382.32
• Mol File: 2536-36-9.mol

Chemical Properties

• Melting Point: 76 °C
• Boiling Point: 438.4±18.0 °C(Predicted)
• Appearance: /
• Density: 1.249±0.06 g/cm3(Predicted)
• PKA: 4.78±0.10(Predicted)
• CAS DataBase Reference: IHDA(CAS DataBase Reference)
• NIST Chemistry Reference: IHDA(2536-36-9)
• EPA Substance Registry System: IHDA(2536-36-9)

Safety Data

• Hazardous Substances Data: 2536-36-9(Hazardous Substances Data)

Usage

Chemical Properties

Colourless solid

Upstream product

• 506-13-8 16-hydroxyhexadecanoic acid 
• 2536-35-8 16-bromohexadecanoic acid 
• 3344-70-5 1,12-dibromododecane 
• 57491-65-3 Methyl 16-iodo-(Z)-9-hexadecenoate 
• 18941-99-6 16-Hydroxy-hexadecin-⁽⁹⁾-saeure 
• 871-91-0 oct-7-yn-1-ol 
• 6557-85-3 6-bromohexyl malonic acid diethyl ester 
• 17696-11-6 8-bromooctanoic acid 
• 18458-50-9 7-octynoic acid methyl ester 
• 10297-09-3 oct-7-ynoic acid 
• 4224-70-8 6-bromohexanoic acid 
• 629-03-8 1 ,6-dibromohexane 
• 103687-88-3 2-(15-Bromo-pentadec-2-ynyloxy)-tetrahydro-pyran 
• 103687-90-7 16-(Tetrahydro-pyran-2-yloxy)-hexadecanenitrile 

Downstream Products

• 34450-18-5 17-octadecynoic acid 
• 109-29-5 15-hexadecanolide 
• 660-65-1 1,18-dioxo-17,34-dioxacyclotetratricontane 
• 506-13-8 16-hydroxyhexadecanoic acid 
• 850347-59-0 (S)-3-N-(tert-butoxycarbonyl)amino-1,2-propanediol 1-palmitate 2-(31-benzyloxycarbonyl-16-hentriaconten)oate 
• 850347-52-3 benzyl 3-hydroxy-(2-hydroxymethyl)-2-methylpropyl 16-dotriacontenedioate 
• 850347-50-1 1-[(30-benzyloxycarbonyl)hentriacont-15-en-1-yl]-4-methyl-2,6,7-trioxabicyclo[2.2.2]octane 
• 850347-55-6 benzyl hydrogen 16-dotriacontenedioate 
• 850347-42-1 benzyl 16-oxohexadecanoate 
• 850347-41-0 benzyl 16-iodohexadecanoate 
• 57-10-3 1-hexadecylcarboxylic acid 

Relevant articles and documents

CT CONTRAST AGENT FOR DETECTION OF CACHEXIA

The invention relates to an iodinated CT contrast agent for non-invasive diagnosis of cachexia. This is possible by superior resolution of CT combined with CT contrast agent specific for the brown and/or beige adipose tissue (BAT).

NANOEMULSION OF IODINATED FATTY ACIDS FOR CT IMAGING

The invention relates to an iodinated CT contrast agent made of fatty acid derivatives for noninvasive visualisation and quantification of the brown and/or beige adipose tissue (BAT) or for imaging the heart and/or liver of a subject. Advantageously, this contrast agent is to be taken orally which is a breakthrough in CT imaging. Image resolution by CT is significantly enhanced compared to PET.

Regio- and chemoselective one-step 3-O-alkylenation of unprotected ascorbic acid using ω-iodoalkanols

A regio- and chemoselective alkylenation employing unprotected ascorbic acid and a series of unprotected iodoalkanols in the presence of sodium hydrogen carbonate in dimethyl sulfoxide is described. This atom economic high yielding procedure delivers the

Identification of very long chain unsaturated fatty acids from Ximenia oil by atmospheric pressure chemical ionization liquid chromatography-mass spectroscopy

A method is described for the enrichment of very long chain unsaturated fatty acids from total fatty acids of Ximenia oil and their identification as picolinyl esters by means of liquid chromatography-mass spectrometry with atmospheric pressure chemical ionization (LC-MS/APCI). The method is based on the use of preparative reversed phase HPLC and their subsequent identification by microbore LC-MS/APCI. The combination of these two techniques was used to identify unusual unsaturated VLCFAs up to tetracontenoic acid. All four positional isomers of tetratriacontenoic acid were also synthesized to unambiguously confirm their structure.

Design and synthesis of asymmetric acyclic phospholipid bolaamphiphiles

(Chemical Equation Presented) A synthetic route was devised for the generation of asymmetric lipid bolaamphiphiles through the sequential esterification of an alkyldioic acid, bearing distinct terminal protecting groups, with propanylamine and lyso-phosph

Initiation and bonding of diamond and other thin films

A method for initiating and bonding thin films on substrates is described. The method employs an interlayer comprising a self-assembling monolayer (SAM). The SAM is formed from monomers, one end of which are capable of bonding to the substrate, and the other end of which form a surface similar to, and capable of initiating the formation of a film. Additionally, compositions for monomers, methods for SAM formation, and methods for film formation are disclosed. In a preferred embodiment the thin film is comprised of diamond.

Synthesis of Very Long Fatty Acid Methyl Esters

Phosphoranes, produced by treating alkyltriphenylphosphonium bromides with lithium hexamethyldisilazide, reacted with ω-oxo esters to give modest yields of the corresponding methyl cis-alkenoates.By an alternative method, treatment of ω-iodo esters with the complexes formed from reactions of alkylcopper(I) and Grignard reagents gave methyl alkanoates, cis-alkenoates, and methylene-interrupted cis,cis-alka-dienoates and cis,cis,cis-trienoates.The stereochemical integrity of the esters was determined by 13C NMR spectroscopy.

Methode de synthese d'acides gras marques substitues ou non en α et en β

2-Propyn-1-ol and the dibromides Br(CH2)nBr (n = 10-12) have been used as starting materials for the synthesis of α- and β-methyl-branched fatty acids (C16) labeled with 123I at the ω-position.The methyl groups are introduced through the use of the lithium salt of either propanoic or isobutyric acid.The synthesis of *IC6H5(CH2)14COOH and *IC6H5(CH2)12CH(CH3)CH2COOH have been achieved in the same way starting from phenylacetylene.In each case, the radioactive iodine atom is introduced by an I/*I exchange reaction.

Acides gras marques en position ω par un nucleide radioactif emetteur γ

The synthesis of many saturated, acetylenic, olefinic (Z or E) fatty acids labeled with 123I or 131I at the ω-position has been achieved.The radioactive iodine atom is introduced by a I-, *I- exchange reaction; the influence on the yield of several parameters - presence of iodine carrier, fatty acid and water concentrations, solution acidity - has been studied.Experimental conditions which produce labeling yields higher than 95percent have been defined; these results have lead to a very easy labeling method used in several hospitals in the external study of myocardial metabolism of fatty acids.

Synthesis and Evaluation of Radioiodinated (E)-18-Iodo-17-octadecenoic Acid as a Model Iodoalkenyl Fatty Acid for Myocardial Imaging

125I-labeled (E)-18-iodo-17-octadecenoic acid (13) has been prepared and evaluated in rats to determine the myocardial uptake and retention and degree of in vivo deiodination of this model iodovinyl-substituted fatty acid, which contains no structural perturbation to inhibit metabolism.This new agent was prepared by NaI-chloramine-T treatment of (17-carbomethoxyheptadec-1-en-1-yl)boronic acid (11) prepared by catecholborane treatment of methyl 17-octadecynoate (10), followed by basic hydrolysis to the free acid (13).The pivotal substrate, 17-octadecynoic acid (9), was prepared by two new routes .The 125I-labeled acid 13 showed high myocardial uptake (1 h, 1.90-2.28percent dose/g) with 45percent washout after 2 h but lower heart/blood ratios in comparison to analogues containing the tellurium heteroatom.Deiodination was low for the first 2 h after injection (2 h, 61percent dose/g).Excellent myocardial images were obtained in a dog with the 123I-labeled agent.