184653-52-9

Upstream product

• 26924-35-6 2-methyl-2-vinyl-1,3-dioxolane 
• 184422-45-5 (R)-(2,3-dimethylcyclohex-1-enyloxy)trimethylsilane 
• 252290-09-8 (4aS,5R)-3,4,4a,5,6,7-hexahydro-4a,5-dimethyl-2H-1-benzopyran-2-one 
• 917-54-4 methyllithium 
• 78-94-4 methyl vinyl ketone 
• 234078-11-6 (2RS,3R)-2,3-dimethylcyclohexanone 

Relevant academic research and scientific papers

A practical and efficient preparation of (-)-(4aS,5R)-4,4a,5,6,7,8-hexahydro-4a,5-dimethyl-2(3H)-naphthalenone: A key intermediate in the synthesis of (-)-dehydrofukinone

A novel diastereoselective route to octalone (-)-1 has been developed. The key step involves an asymmetric Michael addition of the corresponding chiral secondary enamines derived from (S)-(-)-1-phenylethylamine and (3R)-2,3-dimethylcyclohexanone to methyl vinyl ketone. This enone was successfully transformed into the eremophilane-type sesquiterpenoid (-)-dehydrofukinone.

First stereoselective synthesis of (4aS,5R)-4,4a,5,6,7,8-hexahydro-4a,5- dimethyl-2(3H)-naphthalenone

The synthesis of enantiomerically pure (4aS,5R)-hexahydro-4a,5-dimethyl- 2(3H)-naphthalenone (-)-1 is described for the first time. The synthesis starts from (R)-3-methylcyclohexanone and involves the preparation of Piers enol lactone 6 in its enantiopure

An efficient synthesis of the natural (+)-fulvanin 1

Pulegone was used for the first total synthesis of (+)-fulvanin 1 adopting chiron approach. Pertinent methodology includes stereocontrolled Michael-type reaction, functional group adjustments and Wittig olefination.