184698-69-9

Upstream product

• 4539-78-0 2,3,4-tri-O-benzyl-D-glucopyranosideuronic acid benzyl ester 
• 545-06-2 trichloroacetonitrile 

Downstream Products

• 1607445-05-5 1,6-anhydro-4-O-benzyl-3-O-(2-naphthalenylmethyl)-2-O-[N-[benzyl(2,3,4-tri-O-benzyl-α-D-glucopyranosyl)uronate]ethanimidyl]-β-D-mannopyranose 
• 1607444-93-8 [benzyl (2,3,4-tri-O-benzyl-β-D-glucopyranosyl)uronate]-(1→ 2)-1,6-anhydro-4-O-benzyl-3-O-(2-naphthalenylmethyl)-β-D-mannopyranose 
• 1607444-94-9 [benzyl (2,3,4-tri-O-benzyl-α-D-glucopyranosyl)uronate]-(1→ 2)-1,6-anhydro-4-O-benzyl-3-O-(2-naphthalenylmethyl)-β-D-mannopyranose 
• 1599469-73-4 C₆₉H₆₂O₁₄ 

Relevant academic research and scientific papers

The synthesis of the glucuronide adduct of Trocade(TM)

The synthetic preparation of the glucuronide adduct of Trocade(TM), a selective inhibitor of the MMP collagenase, is described. This was achieved by preparation of the protected O-glucuronsyl hydroxylamine (9) and subsequent coupling to the available carboxylic acid (7), followed by deprotection. The synthetic material was identical to authentic isolated metabolite, which confirmed that glucuronidation of Trocade(TM) occurs on the oxygen of the hydroxamic acid. (C) 2000 Published by Elsevier Science Ltd.