184716-91-4Relevant academic research and scientific papers
A study on the asymmetric synthesis of β-lactams through double stereodifferentiating cycloaddition reactions
Palomo, Claudio,Aizpurua, Jesus M.,Mielgo, Antonia,Linden, Anthony
, p. 9186 - 9195 (2007/10/03)
The cycloaddition reaction of chiral aminoketenes, generated from their corresponding acid chlorides and triethylamine, with chiral imines is evaluated as the most direct approach for the construction of cis-β-lactams with the absolute stereochemistry at the C3 and C4 positions being controlled by the ketene partner, independently of the absolute stereochemistry of the imine component.
