16732-82-4 Usage
Uses
Used in Pharmaceutical Industry:
7-METHYL-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER is used as a key intermediate in the synthesis of various drugs and pharmaceuticals, leveraging its chemical structure to enhance the therapeutic efficacy of resulting compounds.
Used in Antibacterial Applications:
7-METHYL-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER is used as an antibacterial agent for its ability to combat bacterial infections, making it a potential candidate for the development of new antimicrobial agents to address the growing concern of antibiotic resistance.
Used in Antifungal Applications:
7-METHYL-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER is used as an antifungal agent, effective against fungal pathogens, and contributing to the development of novel antifungal medications to treat a range of fungal diseases.
Used in Anti-inflammatory Applications:
7-METHYL-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER is used as an anti-inflammatory agent, potentially mitigating inflammation in various conditions, offering a new avenue for the treatment of inflammatory diseases.
Used in Anti-cancer Applications:
7-METHYL-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER is used as an anti-cancer agent, showing promise in the treatment of various types of cancer due to its potential to inhibit cancer cell growth and proliferation, thereby offering new therapeutic options in oncology.
Check Digit Verification of cas no
The CAS Registry Mumber 16732-82-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,7,3 and 2 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 16732-82:
(7*1)+(6*6)+(5*7)+(4*3)+(3*2)+(2*8)+(1*2)=114
114 % 10 = 4
So 16732-82-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H11NO2/c1-7-4-3-5-8-6-9(11(13)14-2)12-10(7)8/h3-6,12H,1-2H3
16732-82-4Relevant academic research and scientific papers
INHIBITORS OF METALLO-BETA-LACTAMASES
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Paragraph 00155-00156, (2017/06/24)
The present invention relates to certain compounds, in particular, indole derivatives that function as inhibitors of bacterial metallo-beta- lactamases. The present invention also relates to processes for the preparation of these compounds, to pharmaceuti
Probing the subpockets of factor Xa reveals two binding modes for inhibitors based on a 2-carboxyindole scaffold: A study combining structure-activity relationship and X-ray crystallography
Nazaré, Marc,Will, David W.,Matter, Hans,Schreuder, Herman,Ritter, Kurt,Urmann, Matthias,Essrich, Melanie,Bauer, Armin,Wagner, Michael,Czech, J?rg,Lorenz, Martin,Laux, Volker,Wehner, Volkmar
, p. 4511 - 4525 (2007/10/03)
Structure-activity relationships within a series of highly potent 2-carboxyindole-based factor Xa inhibitors incorporating a neutral P1 ligand are described with particular emphasis on the structural requirements for addressing subpockets of the factor Xa enzyme. Interactions with the subpockets were probed by systematic substitution of the 2-carboxyindole scaffold, in combination with privileged P1 and P4 substituents. Combining the most favorable substituents at the indole nucleus led to the discovery of a remarkably potent factor Xa inhibitor displaying a Ki value of 0.07 nM. X-ray crystallography of inhibitors bound to factor Xa revealed substituent-dependent switching of the inhibitor binding mode and provided a rationale for the SAR obtained. These results underscore the key role played by the P1 ligand not only in determining the binding affinity of the inhibitor by direct interaction but also in modifying the binding mode of the whole scaffold, resulting in a nonlinear SAR.
