184898-80-4

Upstream product

• 6945-92-2 2-hydrazinyl acetic acid ethyl ester hydrochloride 
• 93-91-4 1-phenylbutan-1,3-dione 

Downstream Products

• 1322724-52-6 1-[2-(3-methyl-5-phenyl-1H-pyrazol-1-yl)acetyl]-4-ethylthiosemicarbazide 
• 1322724-53-7 1-[2-(3-methyl-5-phenyl-1H-pyrazol-1-yl)acetyl]-4-propylthiosemicarbazide 
• 1322724-54-8 1-[2-(3-methyl-5-phenyl-1H-pyrazol-1-yl)acetyl]-4-cyclohexylthiosemicarbazide 
• 1322724-55-9 1-[2-(3-methyl-5-phenyl-1H-pyrazol-1-yl)acetyl]-4-(3-methylphenyl)thiosemicarbazide 
• 1322724-56-0 1-[2-(3-methyl-5-phenyl-1H-pyrazol-1-yl)acetyl]-4-(4-methoxyphenyl)thiosemicarbazide 
• 1322724-57-1 1-[2-(3-methyl-5-phenyl-1H-pyrazol-1-yl)acetyl]-4-(4-nitrophenyl)thiosemicarbazide 
• 1322724-71-9 5-(3-methyl-5-phenyl-1H-pyrazol-1-ylmethyl)-4-ethyl-2H-1,2,4-triazole-3-thione 
• 1322724-72-0 5-(3-methyl-5-phenyl-1H-pyrazol-1-ylmethyl)-4-propyl-2H-1,2,4-triazole-3-thione 
• 1322724-74-2 5-(3-methyl-5-phenyl-1H-pyrazol-1-ylmethyl)-4-(3-methylphenyl)-2H-1,2,4-triazole-3-thione 
• 1322724-77-5 5-(3-methyl-5-phenyl-1H-pyrazol-1-ylmethyl)-4-(4-methoxyphenyl)-2H-1,2,4-triazole-3-thione 
• 184898-81-5 C₁₂H₁₄N₄O 
• 1322724-44-6 5-(3-methyl-5-phenyl-1H-pyrazol-1-ylmethyl)-3H-1,3,4-oxadiazole-2-thione 

Relevant academic research and scientific papers

Design, synthesis, biological evaluation, and computational studies of novel thiazolo-pyrazole hybrids as promising selective COX-2 inhibitors: Implementation of apoptotic genes expression for ulcerogenic liability assessment

A novel series of thiazolo-pyrazole hybrids has been prepared and assessed for their in vitro COX-1/COX-2 inhibitory activity. Compound 6c exhibited the most selective COX-2 inhibition profile (SI of 264) not far of Celecoxib (2 9 4). In-vivo anti-inflamm

2-(1H-Pyrazol-1-yl)acetic acids as chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes (CRTh2) antagonists

In this manuscript, the synthesis and biological activity of a series of pyrazole acetic acid derivatives as CRTh2 antagonists is presented. Biological evaluation in vitro revealed that the pyrazole core showed in several cases a different structure-activity relationship (SAR) to that of related indole acetic acid. A potent series of ortho-sulfonyl benzyl substituents was found, from which compounds 27 and 63 were advanced to in vivo profiling.