1849-03-2

Basic information

• Product Name: 1H-Benzimidazole,2-ethoxy-1-methyl-(9CI)
• Synonyms: 1H-Benzimidazole,2-ethoxy-1-methyl-(9CI)
• CAS NO: 1849-03-2
• Molecular Formula: C10H12N2O
• Molecular Weight: 176.21508
• Product Categories: BENZIMIDAZOLE
• Mol File: 1849-03-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Benzimidazole,2-ethoxy-1-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole,2-ethoxy-1-methyl-(9CI)(1849-03-2)
• EPA Substance Registry System: 1H-Benzimidazole,2-ethoxy-1-methyl-(9CI)(1849-03-2)

Safety Data

• Hazardous Substances Data: 1849-03-2(Hazardous Substances Data)

Usage

Structure

Benzimidazole derivative with an ethoxy and methyl substituent

Industrial applications

Building block in the synthesis of pharmaceuticals, pesticides, and other organic compounds; synthesis of heterocyclic compounds; reagent in chemical research

Biological activity

Potential as a pharmacologically active compound

Upstream product

• 78-09-1 orthocarbonic acid tetraethyl ester 
• 612-28-2 2-nitro-N-methylaniline 
• 64-17-5 ethanol 
• 1849-02-1 2-chloro-1-methyl-benzimidazole 

Relevant articles and documents

Cs2CO3-Promoted C?O Coupling Protocol Enables Solventless (Hetero)aryl Ether Synthesis under Air Atmosphere

In this work, a Cs2CO3-promoted synthetic approach was identified for (hetero)aryl ether synthesis via the C?O coupling of various (hetero)aryl chlorides and alcohols/phenol. To our delight, the reactions could be carried out under transition-metal-free and solvent-free conditions. Moreover, analytical-grade reagents and air atmosphere were readily tolerated. To showcase the practical usefulness of the present protocol, the assembly of a bioactive molecule was facilely realized and the gram-scale production of selected ether products was also efficiently accomplished. In addition, density functional theory (DFT) studies, along with a few mechanistic experiments, were conducted to elucidate a proposed reaction pathway and rationalize the pivotal role of Cs2CO3 in promoting this process. Hopefully, this work could provide useful information for researchers who are engaging in C?O cross-coupling reactions.