1849-03-2Relevant academic research and scientific papers
Cs2CO3-Promoted C?O Coupling Protocol Enables Solventless (Hetero)aryl Ether Synthesis under Air Atmosphere
Jiang, Bowen,Chen, Cheng,Fan, Guang-Gao,Sang, Wei,Cheng, Hua,Zhang, Rui,Yuan, Ye,Li, Qi-Zhong,Verpoort, Francis
, (2022/02/05)
In this work, a Cs2CO3-promoted synthetic approach was identified for (hetero)aryl ether synthesis via the C?O coupling of various (hetero)aryl chlorides and alcohols/phenol. To our delight, the reactions could be carried out under transition-metal-free and solvent-free conditions. Moreover, analytical-grade reagents and air atmosphere were readily tolerated. To showcase the practical usefulness of the present protocol, the assembly of a bioactive molecule was facilely realized and the gram-scale production of selected ether products was also efficiently accomplished. In addition, density functional theory (DFT) studies, along with a few mechanistic experiments, were conducted to elucidate a proposed reaction pathway and rationalize the pivotal role of Cs2CO3 in promoting this process. Hopefully, this work could provide useful information for researchers who are engaging in C?O cross-coupling reactions.
A facile one-pot synthesis of benzimidazoles from 2-nitroanilines by reductive cyclization
Liu, Zheng,Li, Haihong,Zhao, Qingjie,Shen, Jingshan
scheme or table, p. 1907 - 1911 (2009/04/06)
A facile one-pot process to prepare benzimidazole derivatives is described. Reductive cyclization of a serial of 2-nitroanilines with orthoesters in the presence of Pd/C in methanol at room temperature, which is promoted by a catalytic amount of acetic acid, affords the corresponding benzimidazole derivatives in high yields.
