1849-04-3

Basic information

• Product Name: 1H-Benzimidazole,2-methoxy-1-methyl-(9CI)
• Synonyms: 1H-Benzimidazole,2-methoxy-1-methyl-(9CI)
• CAS NO: 1849-04-3
• Molecular Formula: C9H10N2O
• Molecular Weight: 162.1885
• Product Categories: BENZIMIDAZOLE
• Mol File: 1849-04-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Benzimidazole,2-methoxy-1-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole,2-methoxy-1-methyl-(9CI)(1849-04-3)
• EPA Substance Registry System: 1H-Benzimidazole,2-methoxy-1-methyl-(9CI)(1849-04-3)

Safety Data

• Hazardous Substances Data: 1849-04-3(Hazardous Substances Data)

Usage

Structure

Benzimidazole derivative with a methoxy and methyl group attached to the carbon atoms of the benzene ring

Pharmaceutical applications

Potential use in the development of drugs with antiparasitic, antifungal, or antimicrobial properties

Uses and effects

May vary depending on the specific context and formulation; further research and testing are necessary to fully understand its potential applications and implications.

Upstream product

• 67-56-1 methanol 
• 98711-52-5 1-methyl-3-(1-methyl-1,2,4-triazol-4-ylio)benzimidazolium bis-(methyl sulphate) 

Relevant articles and documents

Nucleophilic Substitution in Quaternary Salts of NN'-Linked Biazoles and Related Systems.

Some reactions of dicationic and monocationic N,N'-linked biazoles and of quaternized 1-(N-azolyl)pyridinium ions with nucleophiles have been studied.Although the pyrrolyl nucleus has been found to be a poor leaving group in these reactions, in other cases nucleophilic attack readily takes place at an azolyl carbon atom, with subsequent elimination of the N-substituent.The 1-methyl-3-(1-methyl-1,2,4-triazol-4-ylio)benzimidazolium dication (1) reacted at room temperature with ammonium, diethylamine, methoxyde, hydroxide, and cyanide ions, and with sodium borohydride, giving in all cases the corresponding 2-substituted benzimidazoles in good yield.In the case of the 2,4,6-trimethyl-1-(2-methylpyrazol-1-io)pyridinium dication (6), the reaction with cyanide ion afforded, regioselectively, 5-cyano-1-methylpyrazole, with no trace of the isomeric 3-cyano-1-methylpyrazole.The synthesis of the cations and dications from N-aminoazoles was easily performed.The reaction of 1-aminobenzimidazole with dehydroacetic acid in aqueous hydrochloric acid gave not only the expected 1-benzimidazol-1-yl-2,6-dimethylpyridin-4(1H)-one (9), but also 3-acetyl-1-benzimidazol-1-yl-4-hydroxy-6-methylpyridin-2(1H)-one (11).In pyridine, a pyran-2,4-dione intermediate (10), isomeric to (11), was also isolated.The quaternization reactions were easily performed, but high temperatures caused cleavage of the N-N bond.