1849-49-6

Basic information

• Product Name: 3-HYDROXY-2,5-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE
• Synonyms: 3-HYDROXY-2,5-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE;5-DEOXYPYRIDOXAL;3-Hydroxy-2,5-dimethyl-4-pyridinecarboxaldehyde;3-Hydroxy-2,5-dimethylisonicotinaldehyde;3-hydroxy-2,5-dimethyl-pyridine-4-carbaldehyde;3-hydroxy-2,5-dimethylpyridine-4-carbaldehyde;3-HYDROXY-2,5-DIMETH;2-forMyl-5-hydroxy-3,6-diMethylpyridine-4-carboxylic acid
• CAS NO: 1849-49-6
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.16
• Product Categories: Pyridines
• Mol File: 1849-49-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 318.9 °C at 760 mmHg
• Flash Point: 146.7 °C
• Appearance: /
• Density: 1.206 g/cm³
• Vapor Pressure: 0.000188mmHg at 25°C
• Refractive Index: 1.595
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-HYDROXY-2,5-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-HYDROXY-2,5-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE(1849-49-6)
• EPA Substance Registry System: 3-HYDROXY-2,5-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE(1849-49-6)

Safety Data

• Hazardous Substances Data: 1849-49-6(Hazardous Substances Data)

Usage

General Description

3-Hydroxy-2,5-dimethylpyridine-4-carboxaldehyde is a chemical compound used in the pharmaceutical industry as an intermediate for the synthesis of various drugs, including antimalarial and antitumor agents. It is a heterocyclic compound with a pyridine ring and a hydroxy and aldehyde functional group, making it a versatile building block for chemical synthesis. 3-HYDROXY-2,5-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE has potential applications in drug discovery and development due to its ability to interact with biological receptors and enzymes. Additionally, it is also used in the manufacturing of dyes and pigments, as well as in the synthesis of other specialized chemicals.

InChI:InChI=1/C8H9NO2/c1-5-3-9-6(2)8(11)7(5)4-10/h3-4,11H,1-2H3

Upstream product

• 78313-60-7 2-Methyl-3-hydroxy-4-methoxymethyl-5-chloromethylpyridine hydrochloride 
• 65-22-5 pyridoxal hydrochloride 
• 911142-35-3 2-amino-3-(carboxymethyl-amino)-3-(3-hydroxy-2,5-dimethyl-pyridin-4-yl)-propionic acid 
• 143571-93-1 4-[(E)-Hexyliminomethyl]-2,5-dimethyl-pyridin-3-ol 
• 128669-12-5 4-[(E)-Hexyliminomethyl]-2,5-dimethyl-pyridin-3-ol 
• 4811-03-4 5'-Deoxypyridoxine 
• 220092-30-8 <5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl>methyl acetate 
• 58-56-0 pyridoxal hydrochloride 
• 6562-92-1 chlorhydrate de la 5-(chloromethyl)-2,2,8-trimethyl-4H-1,3-dioxino<4,5-c>pyridine 
• 6953-28-2 (2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol hydrochloride 

Downstream Products

• 132120-36-6 5,8-Dimethyl-3-phenyl-3,4-dihydro-2H-pyrido[4,3-e][1,3]oxazine 
• 132120-30-0 2,5-Dimethyl-4-phenylaminomethyl-pyridin-3-ol 

Relevant articles and documents

INHIBITORS OF THE KYNURENINE PATHWAY

The present application provides novel inhibitors of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase, metabolites thereof, and phannaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. A therapeutically effective amount of one or more of the compounds of formula (I) is useful in treating diseases resulting from dysregulation of the kynurenine pathway. Compounds of formula (I) act by inhibiting the enzymatic activity or expression of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase.

Band-shape Analysis of Electronic Spectra and Study of the Hydrolysis of the Schiff Bases of 5'-Deoxypyridoxal and n-Hexylamine in Aqueous and Non-aqueous Media

The bands of the absorption spectra of the Schiff bases formed between 5'-deoxypyridoxal (DPL) and n-hexylamine in various aqueous solvents (water-dioxane mixtures) and non-aqueous media (dioxane, pentanol-dioxane mixtures, pentanol, butan-2-ol, propanol, ethanol and methanol) have been analysed at 25 deg C.We have also calculated the hydrolysis rate constants of the different tautomers of the Schiff bases.According to our results, the zwitterionic and enol tautomers are more stable on account of the formation of very stable hydrogen bonds.On the other hand, theion-dipole form is the most reactive owing to the absence of stabilizing intramolecular hydrogen bonds and the protonated state of its pyridine nitrogen.The results obtained in this work also show that the relative permittivity of the medium does not significantly affect the tautomeric equilibrium of the chemical species of the Schiff bases of DPL and n-hexylamine.Marshall plots reveal that the microscopic pK most markedly influenced by solvation is that of the phenolic oxygen, whereas that of the pyridine nitrogen is absolutely insensitive to solvation.

Vitamin B6 analogs. An improved synthesis of 5f-deoxypyridoxal.

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