1849-52-1Relevant articles and documents
NOVEL MORPHOLINE DERIVATIVE OR SALT THEREOF
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, (2016/07/05)
There is provided a morpholine derivative represented by General Formula [1A] or a salt thereof. (In the formula, a ring A represents a ring represented by General Formula [I]; * represents a bonding position; Z2 represents CH or the like; Z1 represents CR6 or the like; R6 represents a hydrogen atom or the like; X1 represents CHR7 or the like; R7 represents a hydrogen atom or the like; X2 represents CH2 or the like; R1 and R2 are the same as or different from each other, and each of R1 and R2 represents a hydrogen atom or the like; R3, R4, and R5 are the same as or different from each other, and each of R3, R4, and R5 represents a hydrogen atom, NRaRb, or the like; and each of Ra and Rb represents a hydrogen atom, a C1-8 alkyl group which may have a substituent, or the like.)
Acidity Constants of Benzimidazolium Ketone and Pyridinium Aldehyde Hydrates
Owen, Terence C.
, p. 987 - 990 (2007/10/02)
Acidity constants (pKa) of the hydroxyl groups of the quaternary heterocyclonium carbinols 2-hydroxymethyl-1-methylpyridinium and 2-(1-hydroxyethyl)-1,3-dimethylbenzimidazolium ions are 11.5 +/- 0.5.Acidity constants of the corresponding gem diols, the hydrates of 2-formyl-1-methylpyridinium and 2-acetyl-1,3-dimethylbenzimidazolium ions hence are estimated to be 9 +/- 0.5.Accordingly, acidity constants of the hydroxyl groups of pyridine aldehyde salt hydrates are 12-13, not 4-5 as previously reported; and conversely, acidity constants of the pyridinium groups are 4-5, not 12-13.