654663-32-8

Basic information

• Product Name: 3-METHOXY-4-PYRIDINECARBOXYLIC ACID
• Synonyms: 4-Pyridinecarboxylicacid,3-methoxy-(9CI);3-methoxypyridine-4-carboxylic acid;3-Methoxyisonicotinic acid, 95+%;3-METHOXYISONICOTINIC ACID;3-METHOXY-4-PYRIDINECARBOXYLIC ACID
• CAS NO: 654663-32-8
• Molecular Formula: C₇H₇NO₃
• Molecular Weight: 153.14
• Product Categories: METHOXY;Carboxylic Acids;Pyridines;Carboxylic Acids;CARBOXYLICACID
• Mol File: 654663-32-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 399.5 °C at 760 mmHg
• Flash Point: 195.4 °C
• Appearance: /
• Density: 1.284 g/cm³
• Refractive Index: 1.549
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.84±0.10(Predicted)
• CAS DataBase Reference: 3-METHOXY-4-PYRIDINECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHOXY-4-PYRIDINECARBOXYLIC ACID(654663-32-8)
• EPA Substance Registry System: 3-METHOXY-4-PYRIDINECARBOXYLIC ACID(654663-32-8)

Safety Data

• Hazardous Substances Data: 654663-32-8(Hazardous Substances Data)

Usage

General Description

3-Methoxy-4-pyridinecarboxylic acid, also known as 4-Methoxy-3-pyridinecarboxylic acid, is a chemical compound with the molecular formula C7H7NO3. It is an aromatic carboxylic acid derivative of pyridine, containing a methoxy group at the 3-position of the pyridine ring. 3-Methoxy-4-pyridinecarboxylic acid is used in the synthesis of pharmaceuticals and is also a key intermediate in the production of various organic compounds. It has been studied for its potential biological activities and has shown promising results as an anti-inflammatory and analgesic agent. Additionally, it has been investigated for its potential applications in the treatment of various diseases and conditions.

InChI:InChI=1/C7H7NO3/c1-11-6-4-8-3-2-5(6)7(9)10/h2-4H,1H3,(H,9,10)

Upstream product

• 68325-15-5 3-chloro-isonicotinonitrile 
• 100-48-1 pyridine-4-carbonitrile 
• 1256817-05-6 3-methoxyisonicotinonitrile 
• 26414-90-4 3-methoxypyridine-4-carbonitrile 

Downstream Products

• 59786-32-2 methyl 3-methoxy-4-pyridinecarboxylate 
• 1849-52-1 3-methoxy-4-pyridinecarboxaldehyde 
• 102074-60-2 4-(hydroxymethyl)-3-methoxypyridine 

Relevant articles and documents

Design, synthesis, and biological evaluation of 17-cyclopropylmethyl-3, 14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido] morphinan derivatives as peripheral selective μ opioid receptor agents

Peripheral selective μ opioid receptor (MOR) antagonists could alleviate the symptoms of opioid-induced constipation (OIC) without compromising the analgesic effect of opioids. However, a variety of adverse effects were associated with them, partially due to their relatively low MOR selectivity. NAP, a 6β-N-4′-pyridyl substituted naltrexamine derivative, was identified previously as a potent and highly selective MOR antagonist mainly acting within the peripheral nervous system. The noticeable diarrhea associated with it prompted the design and synthesis of its analogues in order to study its structure-activity relationship. Among them, compound 8 showed improved pharmacological profiles compared to the original lead, acting mainly at peripheral while increasing the intestinal motility in morphine-pelleted mice (ED50 = 0.03 mg/kg). The slight decrease of the ED50 compared to the original lead was well compensated by the unobserved adverse effect. Hence, this compound seems to be a more promising lead to develop novel therapeutic agents toward OIC.

HARMFUL ARTHROPOD CONTROL COMPOSITION, AND FUSED HETEROCYCLIC COMPOUND

Disclosed is a harmful arthropod control composition comprising, as an active ingredient, a fused heterocyclic compound represented by formula (1) [wherein A1 and A2 independently represent a nitrogen atom or the like; R1 and R4 independently represent a halogen atom or the like; R2 and R3 independently represent a halogen atom or the like; R5 and R6 independently represent a linear C1-C6 hydrocarbon group which may be substituted, or the like (provided that both R5 and R6 cannot represent a hydrogen atom simultaneously); and n represents 0 or 1]. The harmful arthropod control composition has an excellent efficacy to control harmful arthropods.

COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS

The present invention provides: an arthropod pests control composition comprising, as active ingredients, a condensed heterocyclic compound and a pyrethroid compound; a method for controlling arthropod pests which comprises applying effective amounts of a condensed heterocyclic compound and a pyrethroid compound to the arthropod pests or a locus where the arthropod pests inhabit; and so on.