184910-20-1

Basic information

• Product Name: (4-broMo-2,6-difluorophenyl)triMethylsilane
• Synonyms: (4-broMo-2,6-difluorophenyl)triMethylsilane
• CAS NO: 184910-20-1
• Molecular Formula: C₉H₁₁BrF₂Si
• Molecular Weight: 265.1699464
• Mol File: 184910-20-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-broMo-2,6-difluorophenyl)triMethylsilane(CAS DataBase Reference)
• NIST Chemistry Reference: (4-broMo-2,6-difluorophenyl)triMethylsilane(184910-20-1)
• EPA Substance Registry System: (4-broMo-2,6-difluorophenyl)triMethylsilane(184910-20-1)

Safety Data

• Hazardous Substances Data: 184910-20-1(Hazardous Substances Data)

Usage

General Description

(4-bromo-2,6-difluorophenyl)trimethylsilane is a chemical compound with the formula C9H10BrF2Si. It is a colorless liquid that is commonly used as a reagent in organic synthesis. The compound contains a bromine atom and two fluorine atoms attached to a phenyl ring, along with three methyl groups attached to a silicon atom. It is an important building block for the construction of organofluorine compounds and is used in the pharmaceutical and agrochemical industries. (4-bromo-2,6-difluorophenyl)trimethylsilane is also utilized in the development of new materials and as a catalyst in various chemical reactions.

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 461-96-1 3,5-difluorobromobenzene 

Downstream Products

• 651326-71-5 6-bromo-2,4-difluoro-3-(trimethylsilyl)benzaldehyde 
• 746630-34-2 1-(4-bromo-2,6-difluorophenyl)ethan-1-one 
• 486414-99-7 (2,6-Difluoro-4-methyl-phenyl)-trimethyl-silane 

Relevant articles and documents

BIARYL DERIVATIVES AS YAP/TAZ-TEAD PROTEIN-PROTEIN INTERACTION INHIBITORS

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; (I) a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.

Fluorine-flanked congested sites: Minimal, though perceptible buttressing effects on the proton mobility of arenes

(2,6-Difluorophenyl)trimethylsilane, -triethylsilane and -triisopropylsilane undergo sec-butyllithium-mediated metalation at the 3- and 4-position (ortho and meta relative to the halogen) in ratios of 99.6:0.4, 98:2 and 95:5, respectively. The steric pressure transmitted by the fluorine atoms can be increased if the trialkylsilyl group is locked up on the other side by a relatively voluminous substituent. Whereas (2,6-difluorophenyl)triethylsilane is attacked by lithium 2,2,6,6-tetramethylpiperidide under deprotonation of the 4- and 5-position in a ratio of 99.4:0.6, the proportion of "ortho"/ "meta" metalation changes to 84:16 when (2-bromo-6-fluorophenyl) triethylsilane acts as the substrate. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.

Thiazole benzamide derivatives and pharmaceutical compositions for inhibiting cell proliferation, and methods for their use

Aminothiazole compounds with mono-/di-substituted benzamide are represented by the Formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, pharmaceutically active metabolites, and pharmaceutically acceptable salts of said metabolites are described. These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.