18494-58-1

Usage

Uses

Used in Organic Synthesis:
1-(azepan-1-yl)octan-1-one is used as a building block in organic synthesis for its ability to be easily modified, leading to the creation of various pharmaceuticals, agrochemicals, and other useful compounds. Its structural features make it a valuable intermediate in the development of new chemical entities.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 1-(azepan-1-yl)octan-1-one is used as a starting material for the synthesis of drugs. Its potential applications include acting as a central nervous system depressant and an anesthetic, which makes it a promising target for the development of new medications, particularly those aimed at treating conditions that require sedation or pain relief.
Used in Agrochemical Production:
1-(azepan-1-yl)octan-1-one also finds use in the agrochemical industry, where it serves as a precursor for the synthesis of various agrochemicals. Its adaptability in chemical reactions allows for the creation of compounds that can be used in pest control and crop protection, contributing to enhanced agricultural productivity and sustainability.
Overall, 1-(azepan-1-yl)octan-1-one's diverse applications across different industries highlight its importance as a versatile chemical compound with significant potential for further research and development.

Upstream product

• 111-49-9 hexamethylene imine 
• 111-64-8 n-octanoic acid chloride 
• 124-07-2 Octanoic acid 

Relevant academic research and scientific papers

Method for preparing amide compound by photocatalysis of nitrogen-containing heterocyclic compound

The invention provides a method for preparing an amide compound by photocatalysis of a nitrogen-containing heterocyclic compound. The method comprises the following steps: mixing the nitrogen-containing heterocyclic compound, organic carboxylic acid and tetrahalomethane in a solvent, adding a catalyst, and reacting under the illumination condition to prepare the amide compound. According to the invention, the organic carboxylic acid, the nitrogen-containing heterocyclic compound containing reactive hydrogen on nitrogen atoms and the tetrahalomethane are used as raw materials, so the raw materials are wide in source, low in cost and high in safety, and large-scale production is facilitated; the halogen simple substance is co-produced in the reaction process, the added value is high, a large amount of waste is prevented from being generated, and the method has high atom economy and environmental friendliness; light conditions are adopted to replace traditional heating and high-pressure conditions, the reaction conditions are mild, environmental pollution is reduced, and the reaction cost is reduced; the method has the advantages of good substrate applicability, mild process conditions, environmental protection, simple process, simple and feasible operation method, and facilitation of popularization and application.

Synthetic method of amide compound

The invention discloses a synthetic method of an amide compound. An organic carboxylic acid compound with the structure of a formula (I) and an amine compound with the structure of a formula (II) aresubjected to a grinding reaction to obtain the amide compound with the structure of a formula (III) in the presence of a coupling reagent. According to the synthetic method, a heat source is not required to be used for heating, and an organic solvent is also not required to be used as a medium, operation is easy, the reaction time is short, post-processing is easy, and industrial production is easy to achieve(Please see the specifications for the formulas).

Dermal penetration enhancement profile of hexamethylenelauramide and its homologues: In vitro versus in vivo behavior of enhancers in the penetration of hydrocortisone

Several amides of cyclic amines were prepared and tested as penetration enhancers in the diffusion of various drugs through hairless mouse skin in vitro. Hexamethylenelauramide (hexahydro-1-lauroyl-1H-azepine) was selected as a broad spectrum penetration enhancer worthy of further study. Later, the duration of the effect of various enhancers on the penetration barrier in vivo was determined by evaluating the in vitro diffusion of hyrocortisone through skins that had been pretreated in vivo. We found that the longer the pretreatment, the smaller the amount of penetrated hydrocortisone. Furthermore, our results suggested that differences exist in the retention of various enhancers in living mouse skin. The in vitro pretreatment experiments revealed that the penetration through dead skin is slow compared with the penetration through living skin. Neither the nature of the receptor phase, nor the increased temperature of the in vitro experiments, explain the striking differences between the in vivo and the in vitro experiments. Finally, the penetration of hydrocortisone through the stratum corneum in the presence of enhancers, as well as the penetration of 1-dodecylhexahydro-2H-azepin-2-one (laurocapram), hexamethylenelauramide, and oleic acid, were determined using a stratum corneum stripping technique. More hydrocortisone penetrated through the stratum corneum during the first 3 h in the presence of hexamethylenelauramide than in the presence of laurocapram or oleic acid.