185-73-9

Usage

Uses

Used in Research and Chemical Synthesis:
1-Oxa-6-thiaspiro[2.5]octane is utilized as a research chemical and in chemical synthesis processes due to its distinctive structure and reactivity, allowing for the exploration of new chemical reactions and the development of novel compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 1-Oxa-6-thiaspiro[2.5]octane is used as a starting material or intermediate in the synthesis of potential drug candidates, leveraging its unique structural features to create new medicinal compounds.
Used in Agrochemical Industry:
1-Oxa-6-thiaspiro[2.5]octane may also find applications in the agrochemical industry, where it could be employed in the development of new pesticides or other agricultural chemicals, taking advantage of its structural properties to enhance effectiveness and selectivity.
Used in Materials Science:
Within the field of materials science, 1-Oxa-6-thiaspiro[2.5]octane could be used as a component in the design and synthesis of new materials with specific properties, such as improved mechanical strength, thermal stability, or other desirable characteristics.
Overall, the potential applications of 1-Oxa-6-thiaspiro[2.5]octane span across various industries, highlighting its versatility and the importance of further research to fully understand and exploit its properties.

Upstream product

• 1072-72-6 Tetrahydrothiopyran-4-one 
• 615-53-2 ethyl N-methyl-N-nitrosocarbamate 
• 1774-47-6 trimethylsulfoxonium iodide 
• 1030268-24-6 trimethylsulphoxonium iodide 
• 186581-53-3 diazomethane 
• 67-56-1 methanol 

Downstream Products

• 38447-82-4 4-methyltetrahydro-2H-thiopyran-4-ol 
• 1221183-91-0 4-((2-methoxy-4-nitrophenoxy)methyl)tetrahydro-2H-thiopyran-4-ol 
• 1458657-36-7 2-((S)-6-((R)-7-fluoro-4-(4-((1,1-dioxo-4-hydroxytetrahydro-2H-thiopyran-4-yl)methoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid 
• 1458654-34-6 methyl 2-((S)-6-((R)-7-fluoro-4-(4-((1,1-dioxo-4-hydroxytetrahydro-2H-thiopyran-4-yl)methoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate 
• 1458654-36-8 1,1-dioxo-4-((4-bromo-3,5-dimethylphenoxy)methyl)tetrahydro-2H-thiopyran-4-ol 
• 1458657-35-6 2-((S)-6-((R)-7-fluoro-4-(4-((4-hydroxytetrahydro-2H-thiopyran-4-yl)methoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid 
• 1373115-06-0 4-[(4-bromo-3,5-dimethylphenoxy)methyl]tetrahydro-2H-thiopyran-4-ol 
• 865136-34-1 3-{2-fluoro-4-[({4'-[(4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy]-2',6'-dimethylbiphenyl-3-yl}methyl)amino]phenyl}propanoic acid 
• 865136-31-8 ethyl 3-(2-fluoro-4-{({4'-[(4-hydroxytetrahydro-2H-thiopyran-4-yl)methoxy]-2',6'-dimethylbiphenyl-3-yl}methyl)[(2-nitrophenyl)sulfonyl]amino}phenyl)propanoate 
• 865136-33-0 ethyl 3-{2-fluoro-4-[({4'-[(4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy]-2',6'-dimethylbiphenyl-3-yl}methyl)amino]phenyl}propanoate 
• 865136-32-9 ethyl 3-(2-fluoro-4-{({4'-[(4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy]-2',6'-dimethylbiphenyl-3-yl}methyl)[(2-nitrophenyl)sulfonyl]amino}phenyl)propanoate 

Relevant academic research and scientific papers

NEW INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS

The present invention relates to compounds of general formula I, wherein the groups R1, R2 and m are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.

NEW INDANYLOXYDIHYDROBENZOFURANYLACETIC ACID DERIVATIVES AND THEIR USE AS GPR40 RECEPTOR AGONISTS

The present invention relates to compounds of general formula I, (I), wherein the groups R1, R2 and m are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.

FUSED CYCLIC COMPOUNDS

The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof. The compound or a salt thereof or a prodrug thereof has a GPR40 receptor function modulating action and is useful as an insulin secretagogue or an agent for the prophylaxis or treatment of diabetes and the like.

AMINOPHENYLPROPANOIC ACID DERIVATIVE

A compound represented by the formula (1): wherein each symbol is as defined in the specification, and a salt thereof and a prodrug thereof unexpectedly have superior GPR40 receptor agonist activity, superior in the properties as a pharmaceutical product such as stability and the like, and can be a safe and useful pharmaceutical agent as a drug for the prophylaxis or treatment of GPR40 receptor related pathology or diseases such as diabetes and the like.

3-(4-BENZYLOXYPHENYL)PROPANOIC ACID DERIVATIVES

The present invention provides a novel compound represented by the formula (I) wherein each symbol is as defined in the specification, a salt thereof and a prodrug thereof having a superior GPR40 receptor function modulating action, which can be used as an insulin secretagogue, an agent for the prophylaxis or treatment of diabetes and the like. They unexpectedly show superior GPR40 receptor agonist activity, and also show superior properties as a pharmaceutical product, such as stability and the like. Thus, they can be safe and useful pharmaceutical agents for the prophylaxis or treatment of GPR40 receptor related diseases in mammals.

SYNTHESIS AND STEREOCHEMISTRY OF 1-OXA-6-HETERASPIROOCTANES. SINGLE-CRYSTAL ANALYSIS OF 6-PHENYL-1-OXA-6-PHOSPHASPIROOCTANE 6-SULFIDE

The synthesis of several 1-oxa-6-heteraspirooctanes is reported herein for the first time.Stereochemical analysis via NMR studies and a single crystal X-ray diffraction analysis of 6-phenyl-1-oxa-6-phosphaspirooctane 6-sulfide have been completed and provide the basis for correlations of structures for other members of the families yet unknown.Epoxidation of cis-2,6-diphenyl-4-thianone with dimethyl-oxosulfonium methylide in DMSO led, surprisingly, to a tertiary alcohol, presumably via ring opening of the expected intermediate epoxide.This is the first example of this type of ring opening in the presence of this base but the reaction time was longer than that normally employed in this process.Since the family members of the parent spirooctanes are rare, an X-ray diffraction analysis was performed on 6-phenyl-1-oxa-6-phosphaspirooctane 6-sulfide.This analysis revealed a space group of Pna21 with cell dimensions of: a=13.056(3) Angstroem, b=14.268(3) Angstroem, and c=6.1522(11) Angstroem.The phosphorinane ring assumes a slightly flattened chair conformation with the phenyl-P bond being equatorial and the P=S bond being axial.The plane of the epoxide is virtually coincident with a pseudo-mirror plane through P(6), C(3), C(9) and S(15).The phenyl group is rotated out of this plane by 28.2 deg.Although the P-C distances (ring carbons) are 1.813(3) Angstroem and 1.819(3) Angstroem, respectively, and appear to be about normal, the P-phenyl bond of 1.813(3) Angstroem is longer than in a few model systems.The C(3)-O(1) bond in the epoxide is axial or rather pseudo axial.Ring deformations are consistent with a few model epoxides the structures of which have been identified.