1850-61-9

Usage

Uses

Used in Pharmaceutical Synthesis:
(1R,2S)-2-[methyl(nitroso)amino]-1-phenylpropan-1-ol is utilized as an intermediate in pharmaceutical synthesis for its potential role in the development of new drugs. Its unique molecular structure and stereochemistry allow it to interact with target molecules in biological systems, contributing to its use in medicinal chemistry.
Used in Organic Synthesis:
In the field of organic synthesis, (1R,2S)-2-[methyl(nitroso)amino]-1-phenylpropan-1-ol serves as a versatile precursor. Its functional groups and chiral center enable it to be a key component in the creation of various organic compounds, further expanding its applications in research and chemical development.
Used in Drug Development and Research:
(1R,2S)-2-[methyl(nitroso)amino]-1-phenylpropan-1-ol is also employed in drug development and research due to its potential to contribute to the discovery and design of novel therapeutic agents. Its unique properties and reactivity make it a promising candidate for exploring new avenues in medicinal applications.

Upstream product

• 50-98-6 ephedrine hydrochloride 
• 299-42-3 ephedrine 

Downstream Products

• 387355-46-6 (1R,2S)-2-(1-Methylhydrazino)-1-phenyl-1-propanol Hydrogenmaleate 
• 252664-34-9 C₂₂H₂₈⁽²⁾HN₃O₅ 
• 252664-13-4 3-{5-[((1S,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-hydrazonomethyl]-4-methoxycarbonylmethyl-1H-pyrrol-3-yl}-propionic acid methyl ester 
• 476013-32-8 (2'S,3'S,5S,6R)-3,4,5,6-tetrahydro-3-(3'-hydroxy-2'-methyl-3'-phenyl-propionyl)-4,5-dimethyl-6-phenyl-2H-1,3,4-oxadiazin-2-one 
• 397332-07-9 (5S,6R)-4,5-dimethyl-6-phenyl-3-propionyl-3,4,5,6-tetrahydro-2H-1,3,4-oxadiazin-2-one 
• 397332-61-5 (5S,6R)-4,5-dimethyl-6-phenyl-3,4,5,6-tetrahydro-2H-1,3,4-oxadiazin-2-one 
• 67462-20-8 (1R,2S)-N-amino-2-methylamino-1-phenyl-1-propanol 

Relevant academic research and scientific papers

Toward the development of a structurally novel class of chiral auxiliaries: Diastereoselective Aldol reactions of a (1R,2S)-ephedrine-based 3,4,5,6-tetrahydro-2H-1,3,4-oxadiazin-2-one

(equation Presented) 8 examples Asymmetric aldol addition reactions have been conducted with (1R,2S)-ephedrine-derived 3,4,5,6-tetrahydro-2H-1,3,4-oxadiazin-2-one (2). Diastereoselectivities range from 75:25 to 99:1 for the formation of the crude non-Evan

X-ray crystallographic and proton nuclear magnetic resonance studies of β-hydroxy-N-nitrosamines derived from α-amino acids and ephedrine

β-Hydroxy-N-nitrosamines derived from L-leucine, L-valine, L-phenylalanine, D-phenylglycine and (1R,2S)-ephedrine have been synthesized and analyzed. These compounds all exhibit rotameric populations of (E)- and (Z)-stereoisomers that are a result of the

Biosynthesis of porphyrins and related macrocycles. Part 52.1'2 Synthesis of 1-SH11-4Hjporphobilinogen and the (11R)enantiomer for stereochemical studies on hydroxymethylbilane synthase (porphobilinogen deaminase)

A synthetic route is devised for the synthesis of (115)-[11-2H,]porphobilinogen la and of the (1 lβ)-enantiomer Ib. Their absolute configurations and enantiomeric purity are established by degradation to a derivative of [2-2H,]glycine of known stereochemistry. Methods are then developed, based on the synthesis of chiral imidate esters, for determination of the configuration of [2H1]-labelled aminomethylpyrroles by converting them into [2H,]-labelled amidines followed by analysis using 'H-NMR. The labelled samples of PEG la and Ib serve as substrates for hydroxymethylbilane synthase and the products are trapped as [2H1]-labelIed aminomethylbilanes 7c and 7d. Their configurations are determined by the NMR assay to demonstrate that as PBG 1 is enzymically converted into the aminomethylbilane 7, there is overall retention of configuration at the aminomethyl carbon. The Royal Society of Chemistry 1999.

N-NITROSATION OF SECONDARY AMINES EFFECTED BY ELECTROCHEMICAL OXIDATION OF NITRITE ION IN WEAKLY BASIC MEDIA

Constant current electrolysis of sodium nitrite in aqueous acetonitrile containing secondary amines at ambient temperature resulted in the formation of the corresponding N-nitrosamines in good yields.KEYWORDS - N-nirosation; secondary amine; sodium nitrite; electrochemical oxidation; constant current electrolysis