67462-20-8

Upstream product

• 1850-61-9 (1R,2S)-N-methyl-N-nitroso-2-amino-1-phenyl-1-propanol 
• 299-42-3 ephedrine 
• 50-98-6 ephedrine hydrochloride 

Downstream Products

• 94068-74-3 4,5-dimethyl-6-phenyl-2-p-tolyl-5,6-dihydro-4H-[1,3,4]thiadiazine 
• 94959-85-0 4,5-dimethyl-2-(4-nitro-phenyl)-6-phenyl-5,6-dihydro-4H-[1,3,4]thiadiazine 
• 93650-24-9 4,5-dimethyl-2,6-diphenyl-5,6-dihydro-4H-[1,3,4]thiadiazine 
• 72518-98-0 N-<(p-methylbenzylidene)amino>ephedrine 
• 82222-49-9 N-<(2-phenylethylidene)amino>ephedrine 
• 72580-52-0 N-(benzylideneamino)ephedrine 
• 72518-99-1 N-<(p-methoxybenzylidene)amino>ephedrine 
• 252664-13-4 3-{5-[((1S,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-hydrazonomethyl]-4-methoxycarbonylmethyl-1H-pyrrol-3-yl}-propionic acid methyl ester 
• 80693-33-0 N-<(α-phenylethylidene)amino>ephedrine 
• 397332-61-5 (5S,6R)-4,5-dimethyl-6-phenyl-3,4,5,6-tetrahydro-2H-1,3,4-oxadiazin-2-one 
• 397332-07-9 (5S,6R)-4,5-dimethyl-6-phenyl-3-propionyl-3,4,5,6-tetrahydro-2H-1,3,4-oxadiazin-2-one 
• 476013-32-8 (2'S,3'S,5S,6R)-3,4,5,6-tetrahydro-3-(3'-hydroxy-2'-methyl-3'-phenyl-propionyl)-4,5-dimethyl-6-phenyl-2H-1,3,4-oxadiazin-2-one 

Relevant academic research and scientific papers

Synthesis and X-ray crystal structures of chiral, nonracemic 5,6-dihydro-4H-1,3,4-oxadiazines

A series of chiral, nonracemic oxadiazines have been prepared from (1R,2S)-ephedrine, (1R,2S)-norephedrine, and L-phenylalaninol. The synthesis of the Ephedra-based oxadiazines was accomplished by a process of N-nitrosation, reduction, acylation, and acid

Toward the development of a structurally novel class of chiral auxiliaries: Diastereoselective Aldol reactions of a (1R,2S)-ephedrine-based 3,4,5,6-tetrahydro-2H-1,3,4-oxadiazin-2-one

(equation Presented) 8 examples Asymmetric aldol addition reactions have been conducted with (1R,2S)-ephedrine-derived 3,4,5,6-tetrahydro-2H-1,3,4-oxadiazin-2-one (2). Diastereoselectivities range from 75:25 to 99:1 for the formation of the crude non-Evan

Inhibitors of copper-containing amine oxidases

The present invention is directed to hydrazono compounds that function as inhibitors of copper-containg amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-1 (VAP-1).

X-ray crystallographic and 13C nuclear magnetic resonance studies of 3,4,5,6-tetrahydro-2H-1,3,4-oxadiazin-2-ones derived from ephedrine and pseudoephedrine

3,4,5,6-Tetrahydro-2H-1,3,4-oxadiazin-2-ones derived from (1R,2S)-ephedrine and (1S,2S)-pseudoephedrine have been synthesized and their conformational properties have been examined. The ephedrine heterocycles 5-7a appear to favor one set of equilibrating

Biosynthesis of porphyrins and related macrocycles. Part 52.1'2 Synthesis of 1-SH11-4Hjporphobilinogen and the (11R)enantiomer for stereochemical studies on hydroxymethylbilane synthase (porphobilinogen deaminase)

A synthetic route is devised for the synthesis of (115)-[11-2H,]porphobilinogen la and of the (1 lβ)-enantiomer Ib. Their absolute configurations and enantiomeric purity are established by degradation to a derivative of [2-2H,]glycine of known stereochemistry. Methods are then developed, based on the synthesis of chiral imidate esters, for determination of the configuration of [2H1]-labelled aminomethylpyrroles by converting them into [2H,]-labelled amidines followed by analysis using 'H-NMR. The labelled samples of PEG la and Ib serve as substrates for hydroxymethylbilane synthase and the products are trapped as [2H1]-labelIed aminomethylbilanes 7c and 7d. Their configurations are determined by the NMR assay to demonstrate that as PBG 1 is enzymically converted into the aminomethylbilane 7, there is overall retention of configuration at the aminomethyl carbon. The Royal Society of Chemistry 1999.