1850-98-2

Usage

Uses

Used in Pharmaceutical Industry:
4,6-dichloro-2-(1-methylethyl)pyrimidine serves as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 4,6-dichloro-2-(1-methylethyl)pyrimidine is utilized as an intermediate for the production of pesticides and other agrochemicals, contributing to the development of effective solutions for crop protection.
Used in Organic Compounds Synthesis:
This chemical compound acts as a building block in the synthesis of a wide range of organic compounds, expanding the scope of chemical research and development.
Used in Research Laboratories:
4,6-dichloro-2-(1-methylethyl)pyrimidine is a valuable compound in research settings, where it is studied for its potential biological and pharmacological activities, paving the way for new discoveries and innovations in the fields of chemistry and medicine.

Upstream product

• 1539-32-8 4-isopropyl-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 4489-34-3 4,6-dichloro-2-(methylsulfonyl)pyrimidine 
• 1197-04-2 4,6-Dihydroxy-2-isopropyl-pyrimidin 

Downstream Products

• 1269612-26-1 N₄,N₆-bis(6-chloro-3,4-diphenylquinolin-2-yl)-2-isopropylpyrimidine-4,6-diamine 

Relevant academic research and scientific papers

Desulfonative photoredox alkylation of: N -heteroaryl sulfones-an acid-free approach for substituted heteroarene synthesis

Minisci-type alkylation of electron-deficient heteroarenes has been a pivotal technique for medicinal chemists in the synthesis of drug-like molecules. However, such transformations usually require harsh conditions (e.g., strong acids, stoichiometric amou

'Green' synthesis of 2-substituted 6-hydroxy-[3H]-pyrimidin-4-ones and 4,6-dichloropyrimidines: Improved strategies and mechanistic study

An improved route to 2-substituted 6-hydroxy-[3H]-pyrimidin-4-ones 4 and to 2-substituted 4,6-dichloropyrimidines 5 is reported. Without using highly toxic reactants, compounds 4 can be prepared conveniently in a one pot synthesis on a one mol scale with average yields up to 80%. 4,6-Dichloropyrimidines 5, which are usually prepared in small quantities, are synthesized with average yields of 80%, using up to 80g of starting material. The mechanism of the chlorination of 4 is investigated computationally for the first time. The results suggest that the chlorination with phosphoryl chloride occurs in an alternating phosphorylation-chlorination manner (pathway 1) which is preferred over a sequence which starts with two phosphorylations. The investigated 4,6-dichloropyrimidines described herein form strong complexes with dichlorophosphoric acid but weak complexes with hydrochloric acid (generated during workup). These latter complexes explain the necessity of using aqueous sodium carbonate during the working up. In order to prevent possible formation of pyrimidinium salts between intermediates or the final dichloropyrimidines and unreacted hydroxypyrimidone, the latter could be deactivated with a strong acid such as dichlorophosphoric acid, thus allowing chlorination but prohibiting salt formation. Because of its general applicability to all nitrogen heterocycle chlorinations with phosphoryl chloride, the proposed route to dichloropyrimidines without solvent or side products, using less toxic reactants, is of general synthetic interest.

Compounds as syk kinase inhibitors

The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by inhibition of Syk kinase.

4-AMINO-PYRIMIDINE DERIVATIVES

4-Amino-pyrimidine derivatives of Formula (I), wherein the meaning of the different substituents are those indicated in the description. These compounds are useful as histamine H4 receptor antagonists.