18501-20-7

Usage

Uses

Used in Pharmaceutical Industry:
1-hydrazino-2-propanol (SALTDATA: FREE) is used as a synthetic intermediate for the development of various medications. Its reducing properties and reactivity make it a valuable component in the synthesis of pharmaceutical compounds, contributing to the creation of new and effective drugs.
Used in Agrochemical Production:
In the agrochemical sector, 1-hydrazino-2-propanol (SALTDATA: FREE) serves as a key precursor in the manufacturing process of various agrochemicals. Its involvement in the synthesis of these products helps in the development of agricultural chemicals that enhance crop protection and yield.
Used in Organic Compounds Manufacturing:
1-hydrazino-2-propanol (SALTDATA: FREE) is utilized as a precursor in the production of other organic compounds. Its unique chemical structure allows it to participate in various chemical reactions, leading to the formation of a wide range of organic products that find use in different industries.
Overall, 1-hydrazino-2-propanol's distinctive chemical properties position it as a valuable asset in multiple industrial applications, from pharmaceuticals and agrochemicals to the broader field of organic compound manufacturing.

InChI:InChI=1/C3H10N2O/c1-3(6)2-5-4/h3,5-6H,2,4H2,1H3

Upstream product

• 503-30-0 trimethylene oxide 
• 78-89-7 2-chloro-1-propanol 
• 127-00-4 1-Chloro-2-propanol 
• 75-56-9 methyloxirane 
• 7803-57-8 hydrazine hydrate 

Downstream Products

• 56360-76-0 C₂₁H₃₀N₆O₄ 
• 80521-52-4 2-Amino-2-methyl-1-phenyl-1-propanone β-Hydroxypropylhydrazone 
• 146324-73-4 1-(2-hydroxypropyl)-3,5-diphenyl-1H-pyrazole 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of new pyrazolyl-ureas and imidazopyrazolecarboxamides able to interfere with MAPK and PI3K upstream signaling involved in the angiogenesis

Taking into account the structure activity relationship information given by our previous studies, we designed and synthesized a small library of pyrazolylureas and imidazopyrazolecarboxamides fluorinated on urea moiety and differently decorated on pyrazo

1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors

In this paper we report the synthesis and the chemotaxis inhibitory activity of a number of 1H-pyrazole-4-carboxylic acid ethyl esters 2 functionalized in N1 with a methyl group or different hydroxyalkyl chains and in position 5 with a series of 3-substituted urea groups. These compounds were designed as development of previous pyrazole-urea derivatives that resulted potent IL8-induced neutrophil chemotaxis inhibitors in vitro. Most of the new compounds revealed a potent inhibition of both IL8- and fMLP-OMe-stimulated neutrophil chemotaxis. The most active compounds in the fMLP-OMe induced chemotaxis test showed IC50 in the range 0.19 nM-2 μM; but we observed a very strong inhibition in the IL8-induced chemotaxis test, having the most active compounds IC50 at pM concentrations. In vivo compounds 2e and 2f, although to a lesser extent, at 50 mg/kg os decreased granulocyte infiltration in zymosan-induced peritonitis in mice.