78-89-7

Usage

InChI:InChI=1/C3H7ClO/c1-3(4)2-5/h3,5H,2H2,1H3

Upstream product

• 67-56-1 methanol 
• 627-68-9 acetic acid-(2-chloro-propyl ester) 
• 187737-37-7 propene 
• 26198-63-0 1,2-Dichloropropane 
• 7623-09-8 2-chloropropionyl chloride 
• 17639-93-9 2-chloro-propionic acid methyl ester 
• 37143-56-9 2-amino-1-chloropropane 
• 107-18-6 allyl alcohol 
• 75-56-9 methyloxirane 
• 14753-25-4 2-chloropropylamine 
• 535-13-7 2-chloro-propanoic acid, ethyl ester 
• 75-77-4 chloro-trimethyl-silane 
• 1066-45-1 trimethyltin(IV)chloride 
• 7550-45-0 titanium tetrachloride 

Downstream Products

• 3565-64-8 Ethyl-(2-chlorpropyl)-ether 
• 3017-96-7 1-bromo-2-chloropropane 
• 18501-20-7 2-hydroxypropylhydrazine 
• 54460-96-7 bis-(2-chloro-propyl) ether 
• 75-56-9 methyloxirane 
• 117729-39-2 (β-hydroxy-isopropyl)-trimethyl-ammonium; chloride 
• 103263-79-2 3,5-dinitro-benzoic acid-(2-chloro-propyl ester) 
• 63483-21-6 Cyclohexyl-carbamic acid 2-chloro-propyl ester 
• 54619-29-3 2-chloro-1-(toluene-4-sulfonyloxy)-propane 
• 72311-96-7 2-ethylthio-2-propanol 
• 111051-50-4 2,2-Diphenyl-5-methyl-1,4-dioxan-3-on 
• 71-23-8 propan-1-ol 
• 26198-63-0 1,2-Dichloropropane 
• 127-00-4 1-Chloro-2-propanol 

Relevant academic research and scientific papers

The liquid containing β - halohydrin of the isolation of the product of the method

The present invention relates to a liquid containing β - process for the isolation of the product of the method, the method comprises: a, β - halo containing liquid product after mixing with the organic extractant extraction, the aqueous phase and the oil phase obtained; b, a distillation step obtained states the oil phase, to obtain the β - halohydrin; the organic extractant comprises a 1st component and 2nd component, the 1st group is divided into not substituted alkanes and/or not substituted olefin, the 2nd group [...] substituted alkanes and/or Cl substituted olefin, the 1st component 2nd component and the molar ratio of 1: (0.05 - 3). The method of simple process flow, low energy consumption, and can separate to obtain a high purity of the halohydrin β -.

ATG7 INHIBITORS AND THE USES THEREOF

Disclosed are chemical entities which are compounds of formula (I) : or a pharmaceutically acceptable salt thereof, wherein R1, R2, and Ra have the values described herein. Chemical entities according to the disclosure can be useful as inhibitors of ATG7. Further provided are pharmaceutical compositions comprising a chemical entity of the disclosure and methods of using the compositions in the treatment of cancer.

Method for preparing halogen propanol and epoxypropane

The invention provides a method for preparing halogen propanol. The method comprises the following steps (1) halogen alcoholization: adding halogen hydride, H2O2, propylene and an HTS molecular sieve into a reaction device, and carrying out halogen alcoholization reaction to obtain the halogen propanol. The invention also provides a method for preparing epoxypropane with a halogenohydrin method. The method comprises the following steps: (1) halogen alcoholization: adding halogen hydride, H2O2, propylene and an HTS molecular sieve into the reaction device, and carrying out the halogen alcoholization reaction to obtain halogen propanol; (2) saponification: carrying out saponification reaction on halogen propanol and a hydroxide of alkali metal in step (1), and separating to obtain the epoxypropane and alkali halide metal salt; optionally (3) electroosmosis: carrying out bipolar membrane electroosmosis on the alkali halide metal salt obtained in step (2) to obtain the hydroxide of alkali metal and the halogen hydride. According to the methods, the halogen propanol or the epoxypropane can be prepared at extremely high selectivity and yield, and the discharging of waste water and waste residues can be drastically lowered.

A convenient method for producing mono- and dichlorohydrins from glycerol

A new method for the transformation of glycerol into mono- and dichlorohydrins has been studied. With trimethylchlorosilane as chlorinating agent and acetic acid as catalyst, mono- and dichlorohydrins have been obtained in high yields and selectivity. In fact, under different reaction conditions, the synthesis of α-monochlorohydrin (3-chloropropan-1,2-diol) or α,γ-dichlorohydrin (1,3-dichloropropan-2-ol) as predominant product has been achieved. This process was also exploited for the valorisation of the crude mixture of glycerol and monochlorohydrin (glyceric mixture), a by-product from an earlier BioDiesel production. A reaction mechanism has been proposed based on investigations on the chlorination of different alcohols.

Dehydrochlorination of 2-chloroethanol, 2-chloro-1-propanol, 1-chloro-2-propanol, 2-chloro-2-methyl-1-propanol and 1-chloro-2-methyl-2- propanol

The reactions between a few 1,2-chlorohydrins and sodium hydroxide have been studied and shown to involve a two-step nucleophilic elimination of hydrogen chloride. The data are given for the slow rate-determining step of 2-chloroethanol 1, 2-chloro-1-propanol 2, 1-chloro-2- propanol 3, 2-chloro-2-methyl-1-propanol 4 and 1-chloro-2-methyl-2-propanol 5. Compounds 4 and 5 gave 2-methyl-1,2-propanediol as the final product instead of oxiranes given by compounds 13. In contrast to some earlier reports the mere water reaction was shown to be almost negligible. In constant ionic strength the base concentration had no effect on the rates whereas at different base concentrations (0.0500.250 mol dm-3) alone the rate of alkaline dehydrochlorination of 1 clearly decreased (103k2, dm 3 mol-1 s-1: 10.0-8.7, respectively). The rate of 2 at constant base concentration (0.010 mol dm-3) and at different ionic strengths (dm3 mol-1: 0.010-0.500) decreased also (103k2, dm3 mol-1 s-1: 76-65, respectively) indicating that the decrease is mainly due to the change in the ionic strength also in the former case. ARKAT-USA, Inc.

The reactions of 4-chloro-2-butanol and 3-chloro-1-butanol with aqueous sodium hydroxide, and 1-chloro-2-propanol and 2-chloro-1-propanol with isopropyl amine

The total reaction of 4-chloro-2-butanol 1 with NaOH(aq) is dominated (74%) by intramolecular substitution (SNi), besides which bimolecular substitution (SN2, 12%) and 1,4-elimination (i.e. fragmentation, contrary to earlier arguments) exhibit a significant contribution (11%). The total reaction of 3-chloro-1-butanol 2 instead is dominated by 1,4-(72%) and 1,2-elimination (25%), the substitution reactions being just observable (SNi 2% and SN2 1%). In 1 both the +I-effect and the conformational factors in the intermediate γ-chloroalkoxy anion favour the SNi-reaction, whereas in 2 the situation is opposite and the location of Cl on a secondary carbon also makes the SNi-reaction less favourable. The relative proportions of 1,4-and 1,2-eliminations for 2 can be explained by thermodynamic basis since the consequent products are more stable than the corresponding products from 1. 1-chloro-2-propanol 3 and 2-chloro-1-propanol 4 both react with isopropyl amine giving the same product, namely 1-isopropylamino-2-propanol, which indicates that the reaction proceeds through the propylene oxide intermediate. Compound 1 also reacted with isopropyl amine predominantly via SNi-reaction, giving first 2-methyloxetane which then further gave 4-isopropylamino-2-butanol, whereas 2 gave 3-isopropylamino-1-butanol through a direct S N2-reaction. ARKAT-USA, Inc.

Asymmetric alkyl-alkyl cross-couplings of unactivated secondary alkyl electrophiles: Stereoconvergent suzuki reactions of racemic acylated halohydrins

A method for asymmetric alkyl-alkyl Suzuki reactions of unactivated secondary alkyl electrophiles, specifically, cross-couplings of racemic acylated halohydrins with alkylborane reagents, has been developed. A range of protected bromohydrins, as well as a protected chlorohydrin and a homologated bromohydrin, are coupled in good ee by a catalyst derived from commercially available components.

Synthesis of oxygen-containing spirobipyrrolidinium salts for high conductivity room temperature ionic liquids

Synthesis of ionic liquids (IL) based on oxygen-containing spirobipyrrolidinium salts with BF4 , BF3C 2F5 , and NTf2 as counterions was undertaken. Their physical and electrochemical properties were evaluated for suitability for Room Temperature Ionic Liquids (RTIL) application. Reduction in melting point occurred upon exchange of C(2) by an O-atom of spirobipyrrolidinium, without sacrificing the electrochemical stability; while introduction of alkyl groups between the N- and O-atoms led to incorporation of asymmetry, and hence reduced the melting points, and viscosity.

CONVERSION OF A MULTIHYDROXYLATED-ALIPHATIC HYDROCARBON OR ESTER THEREOF TO A CHLOROHYDRIN

The present invention relates to a process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of a superatmospheric partial pressure of hydrogen chloride for a sufficient time and at a sufficient temperature, and wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts. In addition, certain catalysts of the present invention may be used in the present process at superatmospheric, atmospheric and subatmospheric pressure conditions with improved results.

Synthesis and extractive power of alkyl-substituted 1,4-dithiane derivatives

The reactions of β,β'-dichlorodialkyl sulfides and β,β'-dichlorodialkyl sulfones with Na2S and Na2S2 were studied, and the extraction power of the reaction products with respect to Au(III) and Pd(II) was examined.