185010-69-9

Basic information

• Product Name: DIETHYL 2-[(3,5-DIFLUOROANILINO)METHYLENE]MALONATE
• Synonyms: DIETHYL 2-[(3,5-DIFLUOROANILINO)METHYLENE]MALONATE;1,3-diethyl 2-{[(3,5-difluorophenyl)amino]methylidene}propanedioate
• CAS NO: 185010-69-9
• Molecular Formula: C₁₄H₁₅F₂NO₄
• Molecular Weight: 299.27
• Mol File: 185010-69-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: DIETHYL 2-[(3,5-DIFLUOROANILINO)METHYLENE]MALONATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL 2-[(3,5-DIFLUOROANILINO)METHYLENE]MALONATE(185010-69-9)
• EPA Substance Registry System: DIETHYL 2-[(3,5-DIFLUOROANILINO)METHYLENE]MALONATE(185010-69-9)

Safety Data

• Hazardous Substances Data: 185010-69-9(Hazardous Substances Data)

Upstream product

• 372-39-4 3,5-difluoroaniline 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Downstream Products

• 1373767-21-5 ethyl 5,7-difluoro-4-oxo-2-(3-(trifluoromethoxy)phenyl)-1,4-dihydroquinoline-3-carboxylate 
• 1373767-20-4 ethyl 5,7-difluoro-4-oxo-2-(3-phenoxyphenyl)-1,4-dihydroquinoline-3-carboxylate 
• 1373767-19-1 ethyl 5,7-difluoro-2-(3-methoxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 185011-62-5 ethyl 5,7-difluoro-4(1H)-quinolone-3-carboxylate 

Relevant articles and documents

QUINOLIN-4-ONE AND 4(1H)-CINNOLINONE COMPOUNDS AND METHODS OF USING SAME

The present disclosure relates to quinolin-4-one and 4(1H)-cinnolinone compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.

Lead optimization of 3-carboxyl-4(1 H)-quinolones to deliver orally bioavailable antimalarials

Malaria is a protozoal parasitic disease that is widespread in tropical and subtropical regions of Africa, Asia, and the Americas and causes more than 800,000 deaths per year. The continuing emergence of multidrug-resistant Plasmodium falciparum drives the ongoing need for the development of new and effective antimalarial drugs. Our previous work has explored the preliminary structural optimization of 4(1H)-quinolone ester derivatives, a new series of antimalarials related to the endochins. Herein, we report the lead optimization of 4(1H)-quinolones with a focus on improving both antimalarial potency and bioavailability. These studies led to the development of orally efficacious antimalarials including quinolone analogue 20g, a promising candidate for further optimization.