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1-(7-methyl-2-phenylimidazo[1,2-a]pyridin-3-yl)-2-phenylethane-1,2-dione **1-(7-methyl-2-phenylimidazo[1,2-a]pyridin-3-yl)-2-phenylethane-1,2-dione** is a dicarbonylated imidazo[1,2-a]pyridine derivative synthesized via copper-catalyzed oxidative cross-coupling, where molecular oxygen serves as the oxidant. This method enables regioselective dicarbonylation at the C-3 position of the imidazoheterocycle, yielding 1,2-diketone products efficiently. The oxygen atoms in the diketone moiety are confirmed to originate from molecular oxygen, not water, as demonstrated by 18O-labeling studies. The reaction offers a practical and environmentally benign approach to accessing structurally diverse 1,2-dicarbonyl imidazo[1,2-a]pyridines.

1850276-58-2

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1850276-58-2 Usage

Chemical structure

The compound consists of a pyridine ring fused with an imidazole ring and a phenyl ring, with a ketone group and a methyl group attached to the pyridine ring.

Molecular weight

Approximately 341.39 g/mol

Potential pharmacological properties

Due to its unique structure, the compound may have potential applications in drug development.

Applications in materials science and organic synthesis

The complex and versatile structure of the compound may have applications in these fields.

Further research and testing

Additional research and testing would be necessary to fully understand and utilize the properties and potential applications of this chemical.

Solubility

The solubility of the compound in various solvents is not provided in the material, but it may vary depending on the specific solvent and conditions.

Stability

The stability of the compound under different conditions (e.g., temperature, pH, light exposure) is not provided in the material and would require further investigation.

Reactivity

The reactivity of the compound with other chemicals or under specific conditions is not provided in the material and would require further study.

Toxicity

The toxicity of the compound is not mentioned in the material, and further research would be needed to determine its safety and potential side effects.

Check Digit Verification of cas no

The CAS Registry Mumber 1850276-58-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,5,0,2,7 and 6 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1850276-58:
(9*1)+(8*8)+(7*5)+(6*0)+(5*2)+(4*7)+(3*6)+(2*5)+(1*8)=182
182 % 10 = 2
So 1850276-58-2 is a valid CAS Registry Number.

1850276-58-2Downstream Products

1850276-58-2Relevant academic research and scientific papers

Copper catalyzed direct aerobic double-oxidative cross-dehydrogenative coupling of imidazoheterocycles with aryl acetaldehydes: An articulate approach for dicarbonylation at C-3 position

Shakoor, S. M. Abdul,Agarwal, Devesh S.,Kumar, Anil,Sakhuja, Rajeev

, p. 645 - 652 (2016)

Direct aerobic oxidative cross-dehydrogenative coupling of aryl acetaldehydes at C-3 position of imidazoheterocycles via copper catalyzed reaction resulted in the synthesis of dicarbonylated imidazoheterocycles in 55-85% yields. The methodology provides a

Regioselective Copper-Catalyzed Oxidative Cross-Coupling of Imidazo[1,2-a]pyridines with Methyl Ketones: An Efficient Route for Synthesis of 1,2-Diketones

Lei, Sai,Chen, Guijun,Mai, Yingying,Chen, Longbin,Cai, Huiyin,Tan, Jingwen,Cao, Hua

, p. 67 - 73 (2016)

An efficient copper-catalyzed oxidative coupling of imidazo[1,2-a]pyridines with methyl ketones to directly generate structurally sophisticated 1,2-dicarbonyl imidazo[1,2-a]pyridine derivatives under oxidative conditions is described. The reaction proceeds in good yields using the environmental friendly molecular oxygen as the oxidant. 18O-Labelling experiments unambiguously established that the oxygen of the dicarbonyl products originated from oxygen rather than from water.

Acenaphthenedione compound having protease modifying activity and its derivatives

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Paragraph 0068; 0069; 0070; 0121; 0122; 0123, (2017/10/07)

The invention relates to an acenaphthenedione compound having protease modifying activity and its derivatives. The acenaphthenedione compound is shown in the description. The acenaphthenedione compound and its derivatives can inhibit a variety of autoimmune diseases.

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