185030-33-5

Upstream product

• 1193-81-3 rac-1-cyclohexylethanol 
• 124-63-0 methanesulfonyl chloride 
• 2043-61-0 cyclohexanecarbaldehyde 

Downstream Products

• 1442432-50-9 ethyl 1-(1-cyclohexylethyl)-2-methyl-1H-pyrrole-3-carboxylate 
• 1442422-98-1 1-(1-cyclohexylethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-N-(oxetan-3-yl)-1H-pyrrole-3-carboxamide 
• 1442432-53-2 1-(1-cyclohexylethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-1H-pyrrole-3-carboxylic acid 
• 1442432-52-1 ethyl 1-(1-cyclohexylethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-1H-pyrrole-3-carboxylate 
• 1442432-51-0 ethyl 5-bromo-1-(1-cyclohexylethyl)-2-methyl-1H-pyrrole-3-carboxylate 

Relevant academic research and scientific papers

BIARYL PYRAZOLES AS NRF2 REGULATORS

The present invention relates to biaryl pyrazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.

PYRROLO CARBOXAMIDES AS MODULATORS OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (ROR?, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASES

The invention provides modulators for the orphan nuclear receptor ROR? and methods for treating ROR? mediated diseases by administrating these novel ROR? modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolo carboxamide compounds of Formula (1) and the enantiomers, diastereomers, N-oxides, tautomers, solvates and pharmaceutically acceptable salts thereof.

PYRAZOLE COMPOUNDS AS JAK INHIBITORS

The present invention relates to compounds of formula (I), wherein R1, R2, R1a, R1b have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.