185031-39-4

Upstream product

• 60-29-7 diethyl ether 
• 42201-43-4 2-allyl-1,3-propanediol 
• 100-39-0 benzyl bromide 

Downstream Products

• 193070-22-3 (±)-4-[(benzyloxy)methyl]-dihydrofuran-2(3H)-one 
• 1398246-19-9 1-[1-(benzyloxy)hex-5-en-2-yloxy]-2,5-dimethoxy-4-methylbenzene 
• 402820-95-5 6-benzyloxymethyl-1-(4-methoxy-benzyloxy)-non-8-en-4-ol 
• 402820-96-6 6-benzyloxymethyl-1-(4-methoxy-benzyloxy)-non-8-en-4-one 
• 402820-98-8 5-benzyloxymethyl-2-[2-(4-methoxy-benzyloxy)-ethyl]-cyclohex-2-enone 
• 402820-97-7 3-benzyloxymethyl-8-(4-methoxy-benzyloxy)-5-oxo-octanal 
• 402820-94-4 (2-bromomethyl-pent-4-enyloxymethyl)-benzene 

Relevant academic research and scientific papers

Efficient Oxidative Cleavage of Tetrahydrofuran-2-methanols to γ-Lactones by a 2-Iodobenzamide Catalyst in Combination with Oxone

An environmentally friendly oxidative cleavage of tetrahydrofuran-2-methanols to the corresponding γ-lactones using a catalytic amount of 2-iodo-N-isopropylbenzamide has been developed. The reaction of various tetrahydrofuran-2-methanols with the catalyst in the presence of Oxone (2 KHSO5·KHSO4·K2SO4) as a co-oxidant in DMF at room temperature successfully affords the corresponding lactones in good to high yields, and recovery of the catalyst is readily accomplished using a reductive work-up. This method is notable because it enables the transformation of tetrahydrofuran-2-methanols to γ-lactones under mild conditions without the use of any toxic heavy metals.

Intramolecular Hydroalkoxylation of Unactivated Alkenes Using Silane-Iodine Catalytic System

A novel catalytic system using I2 and PhSiH3 for the intramolecular hydroalkoxylation of unactivated alkenes is described. NMR study indicated that in situ generated PhSiH2I is a possible active catalytic species. This catalytic system allows an efficient intramolecular hydroalkoxylation of phenyl-, trialkyl-, and 1,1-dialkyl-substituted alkenes as well as a variety of unactivated monoalkyl- and 1,2-dialkyl-substituted alkenes at room temperature. Mechanistic consideration based on significant experimental observations is also discussed.

USE OF (R)-PENCICLOVIR TRIPHOSPHATE FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF VIRAL DISEASES

A method of treatment of: i) HIV-1 infections in mammals, including humans; or ii) HBV infections in mammals, including humans; which method comprises the administration to the human in need of such treatment, an effective amount of the (R)-enantiomer of the triphosphate of a compound of formula (A) or a pharmaceutically acceptable salt thereof; and compounds for use in the method.

Formal total synthesis of (±)-vindoline by tandem radical cyclization

(Equation presented) A formal total synthesis of (±)-vindoline 1 has been achieved featuring the tandem cyclization of radicals produced from the iodoaryl azide 19a.